Structure of PDB 8y0w Chain LC

Receptor sequence

>8y0wLC (length=366) Species: 9606 (Homo sapiens) [Search protein sequence]

CARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPY
AVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMF
APTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPL
VVEDKVEGYKKTKEAVLLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRI
QRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIW
TESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQRAL
RAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVD
KAAAAAAALQAKSDEK

3D structure

PDB

8y0w dormant ribosome with eIF5A, eEF2 and SERBP1

Chain

Resolution

3.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LC	A4 R33 I36 F39 T42 R45 K46 N47 N48 R49 Q50 Y52 V54 S55 A58 H60 Q61 T62 S63 T69 G70 R71 V73 A74 R75 P77 R80 G83 T84 R86 Q89 N94 M95 R97 R100 F102 A103 K106 W108 R109 R110 R114 N116 T117 T118 Q119 R121 K140 K163 T164 K165 K182 Y184 R188 M189 R190 A191 G192 K193 M196 R197 R199 R204 R205 K219 R222 N223 K234 P242 G243 H245 K269 K274 S275 R291 R303 P305 R306 K307 K308 H310 R311 R312 L314 K316 K320 N321 L322 R323 L326 K327 K333 R336 T339 R342 Q343 N346 R350	A2 R31 I34 F37 T40 R43 K44 N45 N46 R47 Q48 Y50 V52 S53 A56 H58 Q59 T60 S61 T67 G68 R69 V71 A72 R73 P75 R78 G81 T82 R84 Q87 N92 M93 R95 R98 F100 A101 K104 W106 R107 R108 R112 N114 T115 T116 Q117 R119 K138 K161 T162 K163 K180 Y182 R186 M187 R188 A189 G190 K191 M194 R195 R197 R202 R203 K217 R220 N221 K232 P240 G241 H243 K267 K272 S273 R289 R301 P303 R304 K305 K306 H308 R309 R310 L312 K314 K318 N319 L320 R321 L324 K325 K331 R334 T337 R340 Q341 N344 R348
BS02	rna	LC	P51 A53 K195 M196	P49 A51 K193 M194

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005791	rough endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8y0w, PDBe:8y0w, PDBj:8y0w
PDBsum	8y0w
PubMed	38698775
UniProt	P36578\|RL4_HUMAN Large ribosomal subunit protein uL4 (Gene Name=RPL4)

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