Structure of PDB 8qoi Chain LC

Receptor sequence

>8qoiLC (length=368) Species: 9606 (Homo sapiens) [Search protein sequence]

MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQ
PYAVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGR
MFAPTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPEL
PLVVEDKVEGYKKTKEAVLLLKKLKAWNDIKKVYASQRMRAGKGKMRNRR
RIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFC
IWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQR
ALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLR
VDKAAAAAAALQAKSDEK

3D structure

PDB

8qoi The structure of the human 80S ribosome at 1.9 A resolution reveals the molecular role of chemical modifications and ions in RNA

Chain

Resolution

1.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LC	M1 A4 P6 R33 N38 F39 H41 T42 N43 R45 K46 N47 N48 R49 Q50 Y52 V54 S55 A58 H60 Q61 T62 S63 T69 G70 A72 V73 A74 R75 I76 P77 R80 G83 T84 R86 Q89 G90 N94 M95 C96 R97 G98 R100 M101 F102 A103 P104 K106 W108 R109 R110 R114 N116 T117 T118 Q119 K120 R121 Y122 K140 R143 K163 T164 K165 N178 K181 K182 Y184 R188 M189 R190 A191 G192 K193 K195 M196 R197 R199 R201 R204 R205 K219 R222 N223 K234 L235 N236 K239 P242 G243 H245 R268 K274 S275 R291 L293 K294 R303 A304 P305 R306 K307 K308 H310 R311 R312 L314 K316 N317 K320 N321 L322 R323 L326 K327 K333 M335 R336 T339 Q343 N346 H347 R350 K353	M1 A4 P6 R33 N38 F39 H41 T42 N43 R45 K46 N47 N48 R49 Q50 Y52 V54 S55 A58 H60 Q61 T62 S63 T69 G70 A72 V73 A74 R75 I76 P77 R80 G83 T84 R86 Q89 G90 N94 M95 C96 R97 G98 R100 M101 F102 A103 P104 K106 W108 R109 R110 R114 N116 T117 T118 Q119 K120 R121 Y122 K140 R143 K163 T164 K165 N178 K181 K182 Y184 R188 M189 R190 A191 G192 K193 K195 M196 R197 R199 R201 R204 R205 K219 R222 N223 K234 L235 N236 K239 P242 G243 H245 R268 K274 S275 R291 L293 K294 R303 A304 P305 R306 K307 K308 H310 R311 R312 L314 K316 N317 K320 N321 L322 R323 L326 K327 K333 M335 R336 T339 Q343 N346 H347 R350 K353
BS02	rna	LC	P51 A53 S55 T107 K195 M196	P51 A53 S55 T107 K195 M196

External links

PDB	RCSB:8qoi, PDBe:8qoi, PDBj:8qoi
PDBsum	8qoi
PubMed	38844527
UniProt	P36578\|RL4_HUMAN Large ribosomal subunit protein uL4 (Gene Name=RPL4)

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