Structure of PDB 8glp Chain LC

Receptor sequence

>8glpLC (length=366) Species: 9606 (Homo sapiens) [Search protein sequence]

CARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPY
AVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMF
APTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPL
VVEDKVEGYKKTKEAVLLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRI
QRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIW
TESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQRAL
RAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVD
KAAAAAAALQAKSDEK

3D structure

PDB

8glp mRNA decoding in human is kinetically and structurally distinct from bacteria.

Chain

Resolution

1.67 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	LC	P51 A53 V54 S55 K195 M196	P49 A51 V52 S53 K193 M194
BS02	rna	LC	A4 R33 N38 F39 H41 T42 N43 R45 K46 N47 N48 R49 Q50 Y52 V54 S55 E56 A58 H60 Q61 T62 S63 T69 G70 A72 V73 A74 R75 I76 P77 V79 R80 G82 G83 T84 R86 Q89 G90 N94 M95 C96 R97 G98 R100 M101 F102 A103 P104 K106 W108 R109 R110 R114 N116 T117 T118 Q119 K120 R121 K140 R143 K163 T164 K165 K172 K173 K175 N178 K181 K182 Y184 R188 R190 A191 G192 K193 K195 M196 R197 R199 R201 R204 R205 K219 R222 N223 K234 L235 N236 K239 P242 G243 H245 R268 K269 K274 S275 R291 L293 K294 R303 A304 P305 R306 K307 K308 I309 H310 R311 R312 L314 K316 N317 K320 N321 L322 R323 L326 K327 K333 M335 R336 T339 R342 Q343 N346 H347 R350 K353	A2 R31 N36 F37 H39 T40 N41 R43 K44 N45 N46 R47 Q48 Y50 V52 S53 E54 A56 H58 Q59 T60 S61 T67 G68 A70 V71 A72 R73 I74 P75 V77 R78 G80 G81 T82 R84 Q87 G88 N92 M93 C94 R95 G96 R98 M99 F100 A101 P102 K104 W106 R107 R108 R112 N114 T115 T116 Q117 K118 R119 K138 R141 K161 T162 K163 K170 K171 K173 N176 K179 K180 Y182 R186 R188 A189 G190 K191 K193 M194 R195 R197 R199 R202 R203 K217 R220 N221 K232 L233 N234 K237 P240 G241 H243 R266 K267 K272 S273 R289 L291 K292 R301 A302 P303 R304 K305 K306 I307 H308 R309 R310 L312 K314 N315 K318 N319 L320 R321 L324 K325 K331 M333 R334 T337 R340 Q341 N344 H345 R348 K351
BS03	MG	LC	F39 N43	F37 N41

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005791	rough endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8glp, PDBe:8glp, PDBj:8glp
PDBsum	8glp
PubMed	37020024
UniProt	P36578\|RL4_HUMAN Large ribosomal subunit protein uL4 (Gene Name=RPL4)

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