Structure of PDB 8fle Chain LC

Receptor sequence

>8fleLC (length=176) Species: 9606 (Homo sapiens) [Search protein sequence]

MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQ
LKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDL
TTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKI
KFPLPHRVLRRQHKPRFTTKRPNTFF

3D structure

PDB

8fle Principles of human pre-60S biogenesis

Chain

Resolution

2.48 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LC	A3 S4 G5 R8 Y63 Q66 F68 K70 P72 R87 M93 Y94 R95 R98 R111 G114 A115 R116 H117 R118 R120 R139 H146 D147 S148 P155 H156 R157 R160 R161 H163 P165 R166 T168 T169 K170 P172 N173 T174 F175 F176	A3 S4 G5 R8 Y63 Q66 F68 K70 P72 R87 M93 Y94 R95 R98 R111 G114 A115 R116 H117 R118 R120 R139 H146 D147 S148 P155 H156 R157 R160 R161 H163 P165 R166 T168 T169 K170 P172 N173 T174 F175 F176
BS02	rna	LC	S42 Y46 S49 K52 K53 K55 S57 R87 H122	S42 Y46 S49 K52 K53 K55 S57 R87 H122

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8fle, PDBe:8fle, PDBj:8fle
PDBsum	8fle
PubMed	37410842
UniProt	Q02543\|RL18A_HUMAN Large ribosomal subunit protein eL20 (Gene Name=RPL18A)

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