Structure of PDB 7xnx Chain LC

Receptor sequence

>7xnxLC (length=365) Species: 9606 (Homo sapiens) [Search protein sequence]

ARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYA
VSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFA
PTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLV
VEDKVEGYKKTKEAVLLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRIQ
RRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIWT
ESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQRALR
APRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDK
AAAAAAALQAKSDEK

3D structure

PDB

7xnx A Dynamic rRNA Ribomethylome Drives Stemness in Acute Myeloid Leukemia.

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LC	R33 I36 N38 F39 H41 T42 R45 K46 N47 R49 Q50 Y52 V54 S55 A58 H60 Q61 T62 S63 T69 G70 A72 V73 A74 R75 P77 R80 G83 T84 R86 Q89 N94 M95 R97 G98 R100 M101 F102 A103 K106 W108 R109 R110 R114 N116 T118 Q119 K120 R121 K140 R143 K163 T164 K165 K172 N178 K181 K182 Y184 R188 R190 A191 G192 K193 M196 R197 R199 R201 R204 R205 K219 R222 N223 K234 L235 N236 P242 G243 H245 R268 K269 K274 S275 R291 L293 K294 R303 P305 R306 K307 K308 I309 R311 R312 L314 K316 N321 L322 R323 K327 K333 T339 Q343 N346 H347 R350	R30 I33 N35 F36 H38 T39 R42 K43 N44 R46 Q47 Y49 V51 S52 A55 H57 Q58 T59 S60 T66 G67 A69 V70 A71 R72 P74 R77 G80 T81 R83 Q86 N91 M92 R94 G95 R97 M98 F99 A100 K103 W105 R106 R107 R111 N113 T115 Q116 K117 R118 K137 R140 K160 T161 K162 K169 N175 K178 K179 Y181 R185 R187 A188 G189 K190 M193 R194 R196 R198 R201 R202 K216 R219 N220 K231 L232 N233 P239 G240 H242 R265 K266 K271 S272 R288 L290 K291 R300 P302 R303 K304 K305 I306 R308 R309 L311 K313 N318 L319 R320 K324 K330 T336 Q340 N343 H344 R347
BS02	rna	LC	P51 A53 V54 S55 K195 M196	P48 A50 V51 S52 K192 M193

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005791	rough endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7xnx, PDBe:7xnx, PDBj:7xnx
PDBsum	7xnx
PubMed	36259929
UniProt	P36578\|RL4_HUMAN Large ribosomal subunit protein uL4 (Gene Name=RPL4)

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