Structure of PDB 6zme Chain LC

Receptor sequence

>6zmeLC (length=368) Species: 9606 (Homo sapiens) [Search protein sequence]

MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQ
PYAVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGR
MFAPTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPEL
PLVVEDKVEGYKKTKEAVLLLKKLKAWNDIKKVYASQRMRAGKGKMRNRR
RIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFC
IWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQR
ALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLR
VDKAAAAAAALQAKSDEK

3D structure

PDB

6zme Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.

Chain

Resolution

3.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LC	M1 R33 N38 F39 T42 L44 R45 K46 N47 N48 R49 Q50 Y52 V54 S55 A58 H60 T62 S63 T69 G70 R71 A72 V73 A74 R75 P77 V79 R80 G83 T84 R86 Q89 N94 M95 R97 R100 M101 F102 P104 W108 R109 R110 R114 N116 T118 Q119 R121 K140 K163 T164 K165 K181 K182 Y184 R188 R190 A191 G192 K193 K195 M196 R197 R199 R204 R205 K219 R222 N223 K234 L235 P242 G243 H245 R268 K269 K274 R291 L293 R303 P305 R306 K307 K308 I309 H310 R311 R312 K316 N321 L322 R323 I324 K327 K333 T339 R342 Q343 N346 H347 R350	M1 R33 N38 F39 T42 L44 R45 K46 N47 N48 R49 Q50 Y52 V54 S55 A58 H60 T62 S63 T69 G70 R71 A72 V73 A74 R75 P77 V79 R80 G83 T84 R86 Q89 N94 M95 R97 R100 M101 F102 P104 W108 R109 R110 R114 N116 T118 Q119 R121 K140 K163 T164 K165 K181 K182 Y184 R188 R190 A191 G192 K193 K195 M196 R197 R199 R204 R205 K219 R222 N223 K234 L235 P242 G243 H245 R268 K269 K274 R291 L293 R303 P305 R306 K307 K308 I309 H310 R311 R312 K316 N321 L322 R323 I324 K327 K333 T339 R342 Q343 N346 H347 R350
BS02	rna	LC	P51 A53 T107 K195 M196	P51 A53 T107 K195 M196

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005791	rough endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6zme, PDBe:6zme, PDBj:6zme
PDBsum	6zme
PubMed	32680882
UniProt	P36578\|RL4_HUMAN Large ribosomal subunit protein uL4 (Gene Name=RPL4)

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