Structure of PDB 8brm Chain LB

Receptor sequence

>8brmLB (length=378) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence]

SHRKFSCCRKGNLGYLPRKRCTRGRGRCKTFPPDVQGAPIHLTAFLGYKA
GCTHVMRFIDHRGSNLHNRQAIDQATIIDAPPMICTAIIGYAKTPKGLRA
VTTVWAAHIAEPAMRRFYRNYFHAEKTAFSTYMKKAADGTYIKEQLGRLK
QHADVIRIVAHTQPALTPLKQKKADIMEIQVNGGANVAEKVDYAYALMEK
PISIKDVFSVGAQIDTISITRGRGFEGVVTRWGVTRLPRKTRRGNRKVAC
IGAWHPANVQYTVARAGQMGYFHRTDTNKQVFMIDTAENPRCCTTEFDLT
DKSINPVGGFVNYGRVQGDFIMIKGTCPGPKRRPVVMRNALLPHRNCPPV
QLQWISTASKFGHGIFETVEERRQFYAK

3D structure

PDB

8brm Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis.

Chain

Resolution

3.33 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LB	S2 H3 R4 K5 F6 S7 C9 R10 K11 G12 N13 L14 G15 Y16 L17 P18 R19 K20 R21 T23 R24 K30 T31 C53 T54 H55 H62 R63 G64 S65 Q75 Y92 L99 T103 T104 W106 R116 R117 F118 R120 F123 H124 T128 F130 S131 T132 Y133 R158 K171 Q172 K173 K174 E179 T221 R222 G223 R224 G225 F226 E227 G228 R232 T236 R237 P239 R240 K241 T242 R243 R244 G245 R247 K248 A250 C251 I252 G253 A254 W255 H256 P257 A258 N259 V260 Q261 Y262 T263 R266 A267 Q269 Y272 H274 R275 T276 T278 N279 K280 G309 V312 N313 Y314 G315 R316 K325 G326 T327 C328 G330 K332 R333 R334 R339 L343 H345 R346 N347 S360 K361 F362 G363 H364 V370 R373 F376 Y377	S1 H2 R3 K4 F5 S6 C8 R9 K10 G11 N12 L13 G14 Y15 L16 P17 R18 K19 R20 T22 R23 K29 T30 C52 T53 H54 H61 R62 G63 S64 Q74 Y91 L98 T102 T103 W105 R115 R116 F117 R119 F122 H123 T127 F129 S130 T131 Y132 R157 K170 Q171 K172 K173 E178 T220 R221 G222 R223 G224 F225 E226 G227 R231 T235 R236 P238 R239 K240 T241 R242 R243 G244 R246 K247 A249 C250 I251 G252 A253 W254 H255 P256 A257 N258 V259 Q260 Y261 T262 R265 A266 Q268 Y271 H273 R274 T275 T277 N278 K279 G308 V311 N312 Y313 G314 R315 K324 G325 T326 C327 G329 K331 R332 R333 R338 L342 H344 R345 N346 S359 K360 F361 G362 H363 V369 R372 F375 Y376

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8brm, PDBe:8brm, PDBj:8brm
PDBsum	8brm
PubMed	36912103
UniProt	A8BRZ3

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