Structure of PDB 7ug7 Chain LB

Receptor sequence

>7ug7LB (length=271) Species: 562 (Escherichia coli) [Search protein sequence]

AVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLLEKNSKSGGRNNNGRITT
RHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGER
RYILAPKGLKAGDQIQSGVDAAIKPGNTLPMRNIPVGSTVHNVEMKPGKG
GQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHM
LRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQ
TKGKKTRSNKRTDKFIVRRRS

3D structure

PDB

7ug7 The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation.

Chain

Resolution

2.58 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	LB	R175 M201	R174 M200
BS02	rna	LB	K7 P8 T9 S10 P11 R13 R14 H15 K18 E35 K36 K39 S40 G41 G42 R43 N44 N45 N46 G47 R48 I49 T50 T51 R52 H53 G56 H58 K59 Q60 A61 Y62 R63 I74 Y83 P85 R87 L95 K97 D98 G99 E100 R101 M146 K147 P148 G149 K150 Q153 L154 A155 R156 S157 A158 G159 T160 Y171 L176 R177 S178 E180 R182 A198 H200 M201 V204 L205 G206 K207 A208 G209 R212 W213 R214 R217 P218 T219 V220 R221 G222 T223 A224 M225 N226 P227 V228 D229 H230 H232 G234 G235 E236 G237 R238 N239 F240 G241 K242 H243 P244 T246 P247 W248 T252 K253 G254 K255 K256 T257 R258 K261 R262 T263 K265 R270 R271	K6 P7 T8 S9 P10 R12 R13 H14 K17 E34 K35 K38 S39 G40 G41 R42 N43 N44 N45 G46 R47 I48 T49 T50 R51 H52 G55 H57 K58 Q59 A60 Y61 R62 I73 Y82 P84 R86 L94 K96 D97 G98 E99 R100 M145 K146 P147 G148 K149 Q152 L153 A154 R155 S156 A157 G158 T159 Y170 L175 R176 S177 E179 R181 A197 H199 M200 V203 L204 G205 K206 A207 G208 R211 W212 R213 R216 P217 T218 V219 R220 G221 T222 A223 M224 N225 P226 V227 D228 H229 H231 G233 G234 E235 G236 R237 N238 F239 G240 K241 H242 P243 T245 P246 W247 T251 K252 G253 K254 K255 T256 R257 K260 R261 T262 K264 R269 R270
BS03	MG	LB	T219 R221	T218 R220
BS04	MG	LB	G235 E236	G234 E235
BS05	MG	LB	T223 H232 G234 N239	T222 H231 G233 N238
BS06	MG	LB	G234 G235	G233 G234

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016740	transferase activity
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0032297	negative regulation of DNA-templated DNA replication initiation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015934	large ribosomal subunit
GO:0022625	cytosolic large ribosomal subunit
GO:1990082	DnaA-L2 complex
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Cellular Component

External links

PDB	RCSB:7ug7, PDBe:7ug7, PDBj:7ug7
PDBsum	7ug7
PubMed	35500116
UniProt	P60422\|RL2_ECOLI Large ribosomal subunit protein uL2 (Gene Name=rplB)

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