Structure of PDB 8rxh Chain LA

Receptor sequence

>8rxhLA (length=258) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence]

GKTVLSCRKGNGSVYQVHGHKRLGPAKLRILDYAERHGYMRGVVKSIEHE
AGRGAALARVEFRHPYKFRRVKELMVAPEGMFTGQSVFCGQKAPLAIGNV
LPLGQITEGCIVCNVEAKPGDRGTLARASGDYCIIISHNHETGRTRLKLP
SGQKKSVPSTSRAMIGIISGGGRIEKPVLKAGNSFYRFRGKRNCWPKVRG
VARNPVEHPHGGGNHQHIGHPSTVSRHSPPGQKVGLIAARRTGRIRGGKA
VKGAWHPE

3D structure

PDB

8rxh Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.

Chain

Resolution

2.93 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	LA	G2 K3 T4 R9 S14 V15 Y16 H19 H21 P26 K181 A182 G183 F186 Y187 N194 W196 V199 A203 R204 N205 V207 E208	G1 K2 T3 R8 S13 V14 Y15 H18 H20 P25 K180 A181 G182 F185 Y186 N193 W195 V198 A202 R203 N204 V206 E207
BS02	rna	LA	G2 S7 C8 G11 N12 G13 Q17 V18 G20 R23 G25 P26 I31 Y34 R37 G39 Y40 R54 R64 Y67 K68 F69 F83 T84 G85 Q86 S87 K93 P95 K119 D122 R123 T125 L126 A127 R128 A129 S130 D132 L150 P151 S152 Q154 K156 R174 I175 V179 L180 A182 S185 K192 R193 W196 P197 K198 V199 R200 G201 V202 H211 G213 G214 N215 H216 Q217 H218 I219 G220 H221 P222 S223 T224 V225 S226 R227 H228 P230 P231 G232 Q233 K234 V235 G236 L237 I238 A239 A240 R241 R242 T243 G244 R245 I246 K253 G254 A255 H257	G1 S6 C7 G10 N11 G12 Q16 V17 G19 R22 G24 P25 I30 Y33 R36 G38 Y39 R53 R63 Y66 K67 F68 F82 T83 G84 Q85 S86 K92 P94 K118 D121 R122 T124 L125 A126 R127 A128 S129 D131 L149 P150 S151 Q153 K155 R173 I174 V178 L179 A181 S184 K191 R192 W195 P196 K197 V198 R199 G200 V201 H210 G212 G213 N214 H215 Q216 H217 I218 G219 H220 P221 S222 T223 V224 S225 R226 H227 P229 P230 G231 Q232 K233 V234 G235 L236 I237 A238 A239 R240 R241 T242 G243 R244 I245 K252 G253 A254 H256
BS03	rna	LA	K22 H50 F69 K73 R174 I175 K177 Y187 R188 R190	K21 H49 F68 K72 R173 I174 K176 Y186 R187 R189
BS04	rna	LA	R247 G248 G249	R246 G247 G248

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005730	nucleolus
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8rxh, PDBe:8rxh, PDBj:8rxh
PDBsum	8rxh
PubMed	38722744
UniProt	Q4FWX5

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