Structure of PDB 8iyj Chain LA

Receptor sequence
>8iyjLA (length=434) Species: 10090 (Mus musculus) [Search protein sequence]
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDDSFNTFFSETG
AGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGH
YTIGKEIVDLVLDRIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERL
SVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNE
AIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQT
NLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDP
RHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINY
QPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHW
YVGEGMEEGEFSEAREDLAALEKDYEEVGVDSVE
3D structure
PDB8iyj Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility.
ChainLA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP LA G10 Q11 A12 Q15 A100 G143 G144 T145 T179 N206 Y224 N228 G10 Q11 A12 Q15 A93 G136 G137 T138 T172 N199 Y217 N221
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0007017 microtubule-based process
GO:0030317 flagellated sperm motility
GO:0036098 male germ-line stem cell population maintenance
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005929 cilium
GO:0031514 motile cilium
GO:0036064 ciliary basal body
GO:0036126 sperm flagellum

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iyj, PDBe:8iyj, PDBj:8iyj
PDBsum8iyj
PubMed37295417
UniProtP05214|TBA3_MOUSE Tubulin alpha-3 chain (Gene Name=Tuba3a)

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