Structure of PDB 8fl3 Chain L9

Receptor sequence

>8fl3L9 (length=194) Species: 9606 (Homo sapiens) [Search protein sequence]

GAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRL
GYKAKQGYVIYRIRVRRGGRYGKPVHHGVNQLKFARSLQSVAEERAGRHC
GALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHRE
MRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLHRYR

3D structure

PDB

8fl3 Principles of human pre-60 S biogenesis.

Chain

Resolution

2.53 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L9	R38 Q57 V60 Y62 H109 D136 H139	R37 Q56 V59 Y61 H99 D126 H129
BS02	rna	L9	G2 Y4 Q8 R12 K14 Q15 R24 R31 P40 R41 R44 K47 R49 R50 K54 A55 Q57 R65 R67 R68 G69 G70 Y81 G82 H86 H87 Q91 K93 F94 A95 R96 S97 E104 R105 R108 A112 W120 S125 Y127 F138 R144 W150 H156 H158 M161 R162 S166 R169 S171 R172 K176 G177 H178 K179 H181 H182 I184 G186 S187 R188 R189 W192 R193 R194 R195 H201 R202 Y203 R204	G1 Y3 Q7 R11 K13 Q14 R23 R30 P39 R40 R43 K46 R48 R49 K53 A54 Q56 R64 R66 R67 G68 G69 Y71 G72 H76 H77 Q81 K83 F84 A85 R86 S87 E94 R95 R98 A102 W110 S115 Y117 F128 R134 W140 H146 H148 M151 R152 S156 R159 S161 R162 K166 G167 H168 K169 H171 H172 I174 G176 S177 R178 R179 W182 R183 R184 R185 H191 R192 Y193 R194
BS03	MG	L9	G175 T183	G165 T173

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0045296	cadherin binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0045471	response to ethanol

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0031672	A band
GO:0044391	ribosomal subunit
GO:0045202	synapse
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8fl3, PDBe:8fl3, PDBj:8fl3
PDBsum	8fl3
PubMed	37410842
UniProt	P61313\|RL15_HUMAN Large ribosomal subunit protein eL15 (Gene Name=RPL15)

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