Structure of PDB 4u3u Chain L8

Receptor sequence

>4u3uL8 (length=233) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

NPLTHSTPKNFGIGQAVQPKRNLSRYVKWPEYVRVQRQKKILSIRLKVPP
TIAQFQYTLDRNTAAETFKLFNKYRPETAAEKKERLTKEAAAVAEAKSKQ
DASPKPYAVKYGLNHVVALIENKKAKLVLIANDVDPIELVVFLPALCKKM
GVPYAIVKGKARLGTLVNQKTSAVAALTEVRAEDEAALAKLVSTIDANFA
DKYDEVKKHWGGGILGNKAQAKMDKRAKNSDSA

3D structure

PDB

4u3u ?

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L8	T27 H28 T30 P31 K32 N33 F34 G35 I36 G37 Q38 Q41 P42 R44 L46 S47 R48 Y49 V50 K51 P53 E54 Y55 R60 R68 L69 E100 K105 R108 S126 K128 P129 K133 Y134 G135 L136 N137 H138 A141 L142 K147 P159 L162 K183 K193 T194 S195 A196 G239 N240 K241 A242 K248	T4 H5 T7 P8 K9 N10 F11 G12 I13 G14 Q15 Q18 P19 R21 L23 S24 R25 Y26 V27 K28 P30 E31 Y32 R37 R45 L46 E77 K82 R85 S103 K105 P106 K110 Y111 G112 L113 N114 H115 A118 L119 K124 P136 L139 K160 K170 T171 S172 A173 G216 N217 K218 A219 K225
BS02	rna	L8	Y55 V56 Q59 R60 K63 R185	Y32 V33 Q36 R37 K40 R162

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0000470	maturation of LSU-rRNA
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0042254	ribosome biogenesis

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4u3u, PDBe:4u3u, PDBj:4u3u
PDBsum	4u3u
PubMed	25209664
UniProt	P17076\|RL8A_YEAST Large ribosomal subunit protein eL8A (Gene Name=RPL8A)

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