Structure of PDB 8fl0 Chain L7

Receptor sequence

>8fl0L7 (length=193) Species: 9606 (Homo sapiens) [Search protein sequence]

EVQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKL
KYLAFLRKRPYHFRAPSRIFWRTVRGMLPHKTKRGQAALDRLKVFDGIPP
PYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKR
KEKAKIHYRKKKQLMRLRKQAEKNVEKKIDKYTEVLKTHGLLV

3D structure

PDB

8fl0 Principles of human pre-60 S biogenesis.

Chain

Resolution

2.91 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L7	R12 G17 R18 K25 L28 S44 Y48 R49 H72 F73 R74 T83 M87 P89 F105 D106 I108 P109 D113 K114 K115 K116 R117 R128 L129 K130 R133 E144 G146 K148 Y149 L156 K161 K165 H167 Y168 R169 K171 K172 M175 R176 K188 V203	R10 G15 R16 K23 L26 S42 Y46 R47 H62 F63 R64 T73 M77 P79 F95 D96 I98 P99 D103 K104 K105 K106 R107 R118 L119 K120 R123 E134 G136 K138 Y139 L146 K151 K155 H157 Y158 R159 K161 K162 M165 R166 K178 V193

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0006417	regulation of translation
GO:0017148	negative regulation of translation
GO:0032496	response to lipopolysaccharide
GO:0042592	homeostatic process
GO:0048246	macrophage chemotaxis
GO:0060425	lung morphogenesis
GO:0071346	cellular response to type II interferon
GO:1901194	negative regulation of formation of translation preinitiation complex

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0015934	large ribosomal subunit
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0045202	synapse
GO:0097452	GAIT complex
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8fl0, PDBe:8fl0, PDBj:8fl0
PDBsum	8fl0
PubMed	37410842
UniProt	P40429\|RL13A_HUMAN Large ribosomal subunit protein uL13 (Gene Name=RPL13A)

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