Structure of PDB 8flc Chain L6

Receptor sequence

>8flcL6 (length=210) Species: 9606 (Homo sapiens)

APSRNGMVLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPA
SGPIRPIVRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPR
RRNKSTESLQANVQRLKEYRSKLILFPRKPSAPKKGDSSAEELKLATQLT
GPVMPVRNVYKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKE
AAEQDVEKKK

3D structure

• PDB: 8flc Principles of human pre-60 S biogenesis.
• Chain: L6
• Resolution: 2.76 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L6	A30 R34	A29 R33
BS02	rna	L6	A2 S4 R5 M8 L10 K11 P12 H13 F14 K16 D17 W18 W25 Q28 P29 R31 K32 I33 R35 R36 K37 R39 K42 R56 R60 P62 R65 Y66 H67 R71 G73 R74 L78 K88 K89 R92 D99 R101 R102 R103 R129 K130 R158 K165 K177 F179 R183 M184 R186 A187 N188 G193 R195 R198	A1 S3 R4 M7 L9 K10 P11 H12 F13 K15 D16 W17 W24 Q27 P28 R30 K31 I32 R34 R35 K36 R38 K41 R55 R59 P61 R64 Y65 H66 R70 G72 R73 L77 K87 K88 R91 D98 R100 R101 R102 R128 K129 R157 K164 K176 F178 R182 M183 R185 A186 N187 G192 R194 R197

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0001824 blastocyst development
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0060348 bone development

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8flc, PDBe:8flc, PDBj:8flc
• PDBsum: 8flc
• PubMed: 37410842
• UniProt: P26373|RL13_HUMAN Large ribosomal subunit protein eL13 (Gene Name=RPL13)