Structure of PDB 8fl3 Chain L6

Receptor sequence

>8fl3L6 (length=203) Species: 9606 (Homo sapiens)

VLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPASGPIRPI
VRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTE
SLQANVQRLKEYRSKLILFPRKPSAPKKGDSSAEELKLATQLTGPVMPVR
NVYKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKEAAEQDVE
KKK

3D structure

• PDB: 8fl3 Principles of human pre-60 S biogenesis.
• Chain: L6
• Resolution: 2.53 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L6	A30 R34	A22 R26
BS02	rna	L6	L10 K11 H13 H15 K16 W18 Q19 W25 Q28 P29 R31 K32 I33 R35 R36 R39 K42 R56 R60 P62 T63 V64 Y66 H67 R71 R74 L78 K88 R92 D99 R101 R102 R103 S106 R129 R158 K165 R183 M184 R186 R190 L191 I194 R198	L2 K3 H5 H7 K8 W10 Q11 W17 Q20 P21 R23 K24 I25 R27 R28 R31 K34 R48 R52 P54 T55 V56 Y58 H59 R63 R66 L70 K80 R84 D91 R93 R94 R95 S98 R121 R150 K157 R175 M176 R178 R182 L183 I186 R190
BS03	MG	L6	K11 H13	K3 H5

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0001824 blastocyst development
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0060348 bone development

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8fl3, PDBe:8fl3, PDBj:8fl3
• PDBsum: 8fl3
• PubMed: 37410842
• UniProt: P26373|RL13_HUMAN Large ribosomal subunit protein eL13 (Gene Name=RPL13)