Structure of PDB 7ls1 Chain L3

Receptor sequence

>7ls1L3 (length=184) Species: 10090 (Mus musculus)

VARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLAK
IRKAARELLTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKI
EDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLD
SQKHIDFSLRSPYGGGRPGRVKRKNAKKGQGGAG

3D structure

• PDB: 7ls1 Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
• Chain: L3
• Resolution: 3.3 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L3	V3 R5 W7 V8 C9 R10 K11 T12 Y13 T15 R17 R18 P19 F20 R38 N39 K40 R41 K47 A76 R80 K121 R127 R131 Q132 R133 H134 V142 N143 I144 P145 S146 F147 I148 R150 S153 P164 Y165 R169 G171 R172 V173 K174 N177	V1 R3 W5 V6 C7 R8 K9 T10 Y11 T13 R15 R16 P17 F18 R36 N37 K38 R39 K45 A74 R78 K119 R125 R129 Q130 R131 H132 V140 N141 I142 P143 S144 F145 I146 R148 S151 P162 Y163 R167 G169 R170 V171 K172 N175

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0045182 translation regulator activity

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0006417 regulation of translation
• GO:0008284 positive regulation of cell population proliferation
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0032040 small-subunit processome
• GO:0043226 organelle
• GO:0045202 synapse
• GO:0098794 postsynapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7ls1, PDBe:7ls1, PDBj:7ls1
• PDBsum: 7ls1
• PubMed: 34815424
• UniProt: Q6ZWN5|RS9_MOUSE Small ribosomal subunit protein uS4 (Gene Name=Rps9)