Structure of PDB 4u6f Chain L3

Receptor sequence

>4u6fL3 (length=386) Species: 559292 (Saccharomyces cerevisiae S288C)

SHRKYEAPRHGHLGFLPRKRAASIRARVKAFPKDDRSKPVALTSFLGYKA
GMTTIVRDLDRPGSKFHKREVVEAVTVVDTPPVVVVGVVGYVETPRGLRS
LTTVWAEHLSDEVKRRFYKNWYKSKKKAFTKYSAKYAQDGAGIERELARI
KKYASVVRVLVHTQIRKTPLAQKKAHLAEIQLNGGSISEKVDWAREHFEK
TVAVDSVFEQNEMIDAIAVTKGHGFEGVTHRWGTKKLPRKTHRGLRKVAC
IGAWHPAHVMWSVARAGQRGYHSRTSINHKIYRVGKGDDEANGATSFDRT
KKTITPMGGFVHYGEIKNDFIMVKGCIPGNRKRIVTLRKSLYTNTSRKAL
EEVSLKWIDTASKFGKGRFQTPAEKHAFMGTLKKDL

3D structure

• PDB: 4u6f ?
• Chain: L3
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L3	S2 H3 R4 K5 Y6 E7 A8 P9 R10 H11 H13 L14 G15 L17 P18 R19 K20 R21 I25 R26 R28 K30 A31 K50 M53 T54 T55 R62 S65 A75 Y92 T95 R97 L99 R100 S101 T103 T104 W106 R116 R117 F118 Y119 K120 N121 Y123 K124 S125 K126 K128 A129 F130 T131 K132 Y133 R150 Y154 R159 Q173 K174 K175 E180 T221 K222 G223 H224 G225 F226 G228 H231 R232 K236 K237 L238 R240 K241 T242 H243 R244 G245 L246 R247 K248 V249 A250 C251 I252 G253 A254 W255 H256 P257 A258 H259 V260 W262 S263 R266 A267 Q269 R270 Y272 S274 R275 T276 I278 N279 G309 V312 H313 K325 C327 I328 G330 R332 K333 R334 Y343 R348 S363 K364 F365 G366 K367 K376 M380 L383 K384	S1 H2 R3 K4 Y5 E6 A7 P8 R9 H10 H12 L13 G14 L16 P17 R18 K19 R20 I24 R25 R27 K29 A30 K49 M52 T53 T54 R61 S64 A74 Y91 T94 R96 L98 R99 S100 T102 T103 W105 R115 R116 F117 Y118 K119 N120 Y122 K123 S124 K125 K127 A128 F129 T130 K131 Y132 R149 Y153 R158 Q172 K173 K174 E179 T220 K221 G222 H223 G224 F225 G227 H230 R231 K235 K236 L237 R239 K240 T241 H242 R243 G244 L245 R246 K247 V248 A249 C250 I251 G252 A253 W254 H255 P256 A257 H258 V259 W261 S262 R265 A266 Q268 R269 Y271 S273 R274 T275 I277 N278 G308 V311 H312 K324 C326 I327 G329 R331 K332 R333 Y342 R347 S362 K363 F364 G365 K366 K375 M379 L382 K383
BS02	MG	L3	K364 G366	K363 G365
BS03	OHX	L3	R167 P170 L171	R166 P169 L170
BS04	OHX	L3	K384 L387	K383 L386

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006364 rRNA processing
• GO:0006412 translation
• GO:0006414 translational elongation
• GO:1990145 maintenance of translational fidelity

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4u6f, PDBe:4u6f, PDBj:4u6f
• PDBsum: 4u6f
• PubMed: 25209664
• UniProt: P14126|RL3_YEAST Large ribosomal subunit protein uL3 (Gene Name=RPL3)