Structure of PDB 7tos Chain L18

Receptor sequence

>7tosL18 (length=116) Species: 562 (Escherichia coli) [Search protein sequence]

DKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAA
STVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHG
RVQALADAAREAGLQF

3D structure

PDB

7tos Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.

Chain

L18

Resolution

2.9 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L18	R9 R10 T12 R13 R16 K17 L21 F92 R94 Q98 Y99 R111 F117	R8 R9 T11 R12 R15 K16 L20 F91 R93 Q97 Y98 R110 F116
BS02	rna	L18	K3 K4 R15 R25 H29 R30 T31 P32 R33 H34 Y36 Q38 I40 G44 S45 V47 V54 E55 K56 K63 Y64 N67 K68 H100 G101 R102	K2 K3 R14 R24 H28 R29 T30 P31 R32 H33 Y35 Q37 I39 G43 S44 V46 V53 E54 K55 K62 Y63 N66 K67 H99 G100 R101

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:7tos, PDBe:7tos, PDBj:7tos
PDBsum	7tos
PubMed	35589706
UniProt	P0C018\|RL18_ECOLI Large ribosomal subunit protein uL18 (Gene Name=rplR)