Structure of PDB 7tos Chain L05

Receptor sequence

>7tosL05 (length=177) Species: 562 (Escherichia coli) [Search protein sequence]

AKLHDYYKDEVVKKLMTEFNYNSVMQVPRVEKITLNMGVGEAIADKKLLD
NAAADLAAISGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFE
RLITIAVPRIRDFRGLSAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRG
LDITITTTAKSDEEGRALLAAFDFPFR

3D structure

PDB

7tos Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.

Chain

L05

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L05	K32 T34 N36 M37 G38 V39 G40 T67 A69 R70 V73 F76 I78 I84 K87 S120 F121 D122 R124 N126 S128 G130 R132 G150 L151 D152 T156	K32 T34 N36 M37 G38 V39 G40 T67 A69 R70 V73 F76 I78 I84 K87 S120 F121 D122 R124 N126 S128 G130 R132 G150 L151 D152 T156
BS02	rna	L05	S23 M25 Q26 Q62 K63 L65 K68 K87 T89 R91	S23 M25 Q26 Q62 K63 L65 K68 K87 T89 R91

Gene Ontology

	Molecular Function
GO:0000049	tRNA binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7tos, PDBe:7tos, PDBj:7tos
PDBsum	7tos
PubMed	35589706
UniProt	P62399\|RL5_ECOLI Large ribosomal subunit protein uL5 (Gene Name=rplE)

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