Structure of PDB 8ylb Chain L

Receptor sequence
>8ylbL (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
IPIVVAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIH
MYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTPGM
RHSLPNSRIMIHQPIQAEEIMKLKKQLYNIYAKHTKQSLQVIESAMERDR
YMSPMEAQEFGILDKVLVHP
3D structure
PDB8ylb Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity.
ChainL
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.92: endopeptidase Clp.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1LZA L E82 H116 Y118 W146 V148 E16 H50 Y52 W80 V82
BS02 A1LZA L L104 S108 Y138 L38 S42 Y72
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8ylb, PDBe:8ylb, PDBj:8ylb
PDBsum8ylb
PubMed38620134
UniProtQ16740|CLPP_HUMAN ATP-dependent Clp protease proteolytic subunit, mitochondrial (Gene Name=CLPP)

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