Structure of PDB 8xvv Chain L

Receptor sequence
>8xvvL (length=3485) Species: 9606 (Homo sapiens) [Search protein sequence]
KKYLQFVAALTDVNTPDETKLKMMQEVSENFENVTSSPQYSTFLEHIIPR
FLTFLQDGELQEKPAQQLRKLVLEIIHRIPTNEHLRPHTKNVLSVMFRFL
ETENEENVLICLRIIIELHKQFRPPITQEIHHFLDFVKQIYKELPKVVNR
YFENTHSIIPRGSLSLKVLAELPIIVVLMYQLYKLNIHNVVAEELYADFI
AAQIKTLSFLAYIIRIYQELVTKYSQQMVKGMLQLLSNCPAETAHLRKEL
LIAAKHILTTELRNQFIPCMDKLFDESILIGSGYTARETLRPLAYSTLAD
LVHHVRQHLPLSDLSLAVQLFAKNIDDESLPSSIQTMSCKLLLNLVDCIR
SKSEQESGNGRDVLMRMLEVFVLKFHTIARYQLSAIFKKCKPQSDKEDKQ
TFQVTDCRSLVKTLVCGVKTITWGITSCKQFIPNKQLQPKETQIYIKLVK
YAMQALDIYQVQIAGNGQTYIRVANCQTVRMKEEKEVLEHFAGVFTMMNP
LTFKEIFQTTVPYMVERISKNYALQIVANSFLANPTTSALFATILVEYLL
DRLPEMGSNVELSNLYLKLFKLVFGSVSLFAAENEQMLKPHLHKIVNSSM
ELAQTAKEPYNYFLLLRALFRSIGGGSHDLLYQEFLPLLPNLLQGLNMLQ
SGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSQTLVSQ
GLRTLELCVDNLQPDFLYDHIQPVRAELMQALWRTLRNPADSISHVAYRV
LGKFGGSNRKMLKESQKLHYVVTEVQGPSITVEFSDCKASLQLPMEKAIE
TALDCLKSANTEPYYRRQAWEVIKCFLVAMMSLEDNKHALYQLLAHPNFT
EKTIPNVIISHRYKAQDTPARKTFEQALTGAFMSAVIKDLRPSALPFVAS
LIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMFHSEENGSKGMDPLVLID
AIAICMAYEEKELCKIGEVALAVIFDVASIILGSKERACQLPLFSYIVER
LCACCYEQAWYAKLGGVVSIKFLMERLPLTWVLQNQQTFLKALLFVMMDL
TGEVSNGAVAMAKTTLEQLLMRCATPLKDEERAEEIVAAQEKSFHHVTHD
LVREVTSPNSTVRKQAMHSLQVLAQVTGKSVTVIMEPHKEVLQDMVPPKK
HLLRHQPANAQIGLMEGNTFCTTLQPRLFTMDLNVVEHKVFYTELLNLCE
AEDSALTKLPCYKSLPSLVPLRIAALNALAACNYLPQSREKIIAALFKAL
NSTNSELQEAGEACMRKFLEGATIEVDQIHTHMRPLLMMLGDYRSLTLNV
VNRLTSVTRLFPNSFNDKFCDQMMQHLRKWMEVVVITHKGGQRSDGNEMK
ICSAIINLFHLIPAAPQTLVKPLLEVVMKTERAMLIEAGSPFREPLIKFL
TRHPSQTVELFMMEATLNDPQWSRMFMSFLKHKDARPLRDVLAANPNRFI
TLLLMRLDLQFQAIKIISIIVKNDDSWLASQHSLVSQLRRVWVSENFQER
HRKENMAATNWKEPKLLAYCLLNYCKRNYGDIELLFQLLRAFTGRFLCNM
TFLKEYMEEEIPKNYSIAQKRALFFRFVDFNDPNFGDELKAKVLQHILNP
AFLYSFEKGEDNPESITSVFITKVLDPEKQADMLDSLRIYLLQYATLLVE
HAPHHIHDNNKNRNSKLRRLMTFAWPCLLSKACVDPACKYSGHLLLAHII
AKFAIHKKIVLQVFHSLLKAHAMEARAIVRQAMAILTPAVPARMEDGHQM
LTHWTRKIIVEEGHTVPQLVHILHLIVQHFKVYYPVRHHLVQHMVSAMQR
LGFTPSVTIEQRRLAVDLSEVVIKWELQRIKDIDKQHTDTVVNFLIRVAC
QVNDNTNTAGSPGEVLSRRCVNLLKTALRPDMWPKSELKLQWFDKLLMTV
EQPNQVNYGNICTGLEVLSFLLTVLQSPAILSSFKPLQRGIAACMTCGNT
KVLRAVHSLLSRLMSIFPTEPSTSSVASKYEEECLYAAVGKVIYEGLTNY
NPSQLFGTLMILKSACSNNPSYIDRLISVFMRSLQKMVREHLGTSELVML
SLELVKTRLAVMSMEMRKNFIQAILTSLIEKSPDAKILRAVVKIVEEWVK
NNSNQTPTLREKSILLVKMMTYIEKRFPEDLELNAQFLDLVNYVYRDETL
SGSELTAKLEPAFLSGLRCAQPLIRAKFFEVFDNSMKRRVYERLLYVTCS
QNWEAMGNHFWIKQCIELLLAVCEKSTPIGTSCQGAMLPSITNVINLADS
HDRAAFAMVGNQLHMLTNRHDKFLDTLREVKTGALLSAFVQLCHISTTLA
EKTWVQLFPRLWKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCF
VEAMSQCVPPIPIRPCVLKYLGKTHNLWFRSTLMLEHQAFEKPQQEILDS
LAELYSLLQEEDMWAGLWQKRCKYSETATAIAYEQHGFFEQAQESYEKAM
DKAKKEHERSNASPAIFPEYQLWEDHWIRCSKELNQWEALTEYGQSKGHI
NPYLVLECAWRVSNWTAMKEALVQVEVSCPKEMAWKVNMYRGYLAICHPE
EQQLSFIERLVEMASSLAIREWRRLPHVVSHVHTPLLQAAQQIIELQEAA
QINAGLQPTNLGRNNSLHDMKTVVKTWRNRLPIVSDDLSHWSSIFMWRQH
HYQAIVTAYENSSQHDPSSNNAMLGVHASASAIIQYGKIARKQGLVNVAL
DILSRIHTIPTVPIVDCFQKIRQQVKCYLQLAGVMGKNECMQGLEVIEST
NLKYFTKEMTAEFYALKGMFLAQINKSEEANKAFSAAVQMHDVLVKAWAM
WGDYLENIFVKERQLHLGVSAITCYLHACRHQNESKSRKYLAKVLWLLSF
DDDKNTLADAVDKYCIGVPPIQWLAWIPQLLTCLVGSEGKLLLNLISQVG
RVYPQAVYFPIRTLYLTLKIEQRERYKSDPGPIRATAPMWRCSRIMHMQR
ELHPTLLSSLEGIVDQMVWFRENWHEEVLRQLQQGLAKCYSVAFEKSGAV
SDAKITPHTLNFVKKLVSTFGVGFSSAASESLARRAQATAQDPVFQKLKG
QFTTDFDFSVPGSMKLHNLISKLKKWIKILEAKTKQLPKFFLIEEKCRFL
SNFSAQTAEVEIPGEFLMPKPTHYYIKIARFMPRVEIVQKHNTAARRLYI
RGHNGKIYPYLVMNDACLTESRREERVLQLLRLLNPCLEKRKETTKRHLF
FTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGIEHDNPISRYYDR
LATVQARGTQASHQVLRDILKEVQSNMVPRSMLKEWALHTFPNATDYWTF
RKMFTIQLALIGFAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDAT
GDLDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDG
ILKTVLRDEIIAWHKKTQEDTSGQPENMDSQQLVSLVQKAVTAIMTRLHN
LAQFEGGESKVNTLVAAANSLDNLCRMDPAWHPWL
3D structure
PDB8xvv Structure of the human TIP60 complex
ChainL
Resolution3.2 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IHP L K3017 R3020 K3021 R3051 K3055 K3125 K3165 K3168 K3529 F3735 K2688 R2691 K2692 R2722 K2726 K2796 K2836 K2839 K3190 F3396
Gene Ontology
Molecular Function
GO:0003712 transcription coregulator activity
GO:0005515 protein binding
GO:0016301 kinase activity
Biological Process
GO:0006281 DNA repair
GO:0006282 regulation of DNA repair
GO:0006325 chromatin organization
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0019219 regulation of nucleobase-containing compound metabolic process
GO:0042981 regulation of apoptotic process
GO:0043484 regulation of RNA splicing
GO:0045893 positive regulation of DNA-templated transcription
GO:0051726 regulation of cell cycle
GO:0080135 regulation of cellular response to stress
GO:1905168 positive regulation of double-strand break repair via homologous recombination
GO:2000779 regulation of double-strand break repair
Cellular Component
GO:0000124 SAGA complex
GO:0000786 nucleosome
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0033276 transcription factor TFTC complex
GO:0035267 NuA4 histone acetyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xvv, PDBe:8xvv, PDBj:8xvv
PDBsum8xvv
PubMed39154037
UniProtQ9Y4A5|TRRAP_HUMAN Transformation/transcription domain-associated protein (Gene Name=TRRAP)

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