Structure of PDB 8tov Chain L

Receptor sequence
>8tovL (length=199) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
PIVMVHQCISPRTLNAWVKVVEEKAFSPEVIPMFSALSCGATPQDLNTML
NTVGGHQAAMQMLKETINEEAAEWDRLHPVGPIAPGQMREPRGSDIAGTT
STLQEQIGWMTHNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPK
EPFRDYVDRFYKTLRAETLLVQNANPDCKTILKALGPGATLEEMMTACQ
3D structure
PDB8tov Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators.
ChainL
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J6U L N53 L56 N57 M66 K70 I73 N74 S102 A105 G106 T107 Y130 N47 L50 N51 M60 K64 I67 N68 S94 A97 G98 T99 Y122
Gene Ontology

View graph for
Biological Process
External links
PDB RCSB:8tov, PDBe:8tov, PDBj:8tov
PDBsum8tov
PubMed38054267
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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