Structure of PDB 8r08 Chain L

Receptor sequence
>8r08L (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
MFAEIMMKIEEYISKQEYRVIVDANNLTVEIENELNIIHKFIRDKYSKRF
PELESLVPNALDYIRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTAS
TTQGQQLSEEELERLEEACDMALELNASKHRIYEYVESRMSFIAPNLSII
IGASTAAKIMGVAGGLTNLSKMPACNIMLLGAQSVLPHTGYIYHSDIVQS
LPPDLRRKAARLVAAKCTLAARVDSFHESTEGKVGYELKDEIERKFDKWQ
EKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKQANRMSFGEIEEDAYQ
E
3D structure
PDB8r08 Structural insights into the cross-exon to cross-intron spliceosome switch
ChainL
Resolution6.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna L A246 C247 L251 G253 A254 Q255 P269 H270 K290 K353 R354 R357 M362 A174 C175 L179 G181 A182 Q183 P187 H188 K208 K264 R265 R268 M273
BS02 rna L G355 G356 G266 G267
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030621 U4 snRNA binding
GO:0030622 U4atac snRNA binding
GO:0030674 protein-macromolecule adaptor activity
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
GO:0070990 snRNP binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0048254 snoRNA localization
GO:0071166 ribonucleoprotein complex localization
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005687 U4 snRNP
GO:0005690 U4atac snRNP
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071011 precatalytic spliceosome
GO:0071339 MLL1 complex
GO:0097526 spliceosomal tri-snRNP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8r08, PDBe:8r08, PDBj:8r08
PDBsum8r08
PubMed38778104
UniProtQ8WWY3|PRP31_HUMAN U4/U6 small nuclear ribonucleoprotein Prp31 (Gene Name=PRPF31)

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