Structure of PDB 8qjs Chain L

Receptor sequence
>8qjsL (length=146) Species: 9606 (Homo sapiens) [Search protein sequence]
VLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHS
YRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKER
CLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIA
3D structure
PDB8qjs PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.
ChainL
Resolution3.191 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VL6 L R69 P71 W88 Y98 P99 R107 I109 H110 S111 Y112 H115 W117 R8 P10 W27 Y37 P38 R46 I48 H49 S50 Y51 H54 W56
External links
PDB RCSB:8qjs, PDBe:8qjs, PDBj:8qjs
PDBsum8qjs
PubMed38180485
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

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