Structure of PDB 8ovc Chain L

Receptor sequence

>8ovcL (length=551) Species: 1772 (Mycolicibacterium smegmatis)

ELEARRPFPERMGPKGNLIYKLITTTDHKLIGIMYCVVCFAFFLVGGLMA
LFMRTELAMPGLQFLSNEQFNQLFTMHGTVMLLFYATPIVFGFANLVLPL
QIGAPDVAFPRLNALSFWLFLFGALIAIAGFITPGGAADFGWTAYSPLTD
AIHSPGAGGDLWIMGLAVGGLGTILGGVNMITTVVCMRAPGMTMFRMPIF
TWNILVTSILVLIAFPILTAALFGLAADRHLGAHIYDPANGGVLLWQHLF
WFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLIYATLAIAALSVA
VWAHHMYATGAVLLPFFSFMTFLIAVPTGIKFFNWIGTMWKGQLTFETPM
LFSVGFLITFLLGGLSGVLLASPPLDFHVTDSYFVIAHFHYVLFGTIVFA
TYAGIYFWFPKMTGRLLDERLGKLHFWLTFIGFHTTFLVQHWLGDEGMPR
RYADYLPTDGFTTLNVISTVGAFILGVSMLPFVWNVFKSWRYGEPVTVDD
PWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHMVERMRAEAH
V

3D structure

• PDB: 8ovc Long-range charge transfer mechanism of the III 2 IV 2 mycobacterial supercomplex.
• Chain: L
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEA	L	W151 W260 V267 Y268 H313 H314 G338 G373 D385 T389 H397 F398 V401 L402	W142 W251 V258 Y259 H304 H305 G329 G364 D376 T380 H388 F389 V392 L393
BS02	HEA	L	F52 G56 M62 R63 H86 M90 L91 W151 Y392 F398 H399 L402 F446 R460 L484	F43 G47 M53 R54 H77 M81 L82 W142 Y383 F389 H390 L393 F437 R451 L475
BS03	CU	L	H264 H313 H314	H255 H304 H305
BS04	CA	L	E65 M68 G70 Q72	E56 M59 G61 Q63
BS05	9XX	L	V54 I141	V45 I132

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006119 oxidative phosphorylation
• GO:0009060 aerobic respiration
• GO:0015990 electron transport coupled proton transport
• GO:0022904 respiratory electron transport chain

Cellular Component

• GO:0005886 plasma membrane

External links

• PDB: RCSB:8ovc, PDBe:8ovc, PDBj:8ovc
• PDBsum: 8ovc
• PubMed: 38902248
• UniProt: A0A2U9PNL2