Structure of PDB 8ipx Chain L

Receptor sequence

>8ipxL (length=112) Species: 9606 (Homo sapiens) [Search protein sequence]

PSRLRKTRKLRGHVSHGHGVGMKHYHLKRNQSFCPTVNLDKLWTLVSEQT
RVNAAKNKTGAAPIIDVVRSGYYKVLGKGKLPKQPVIVKAKFFSRRAEEK
IKSVGGACVLVA

3D structure

PDB

8ipx Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.

Chain

Resolution

4.3 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L	P2 S3 R4 R6 K7 T8 R9 K10 R12 H14 V15 S16 H17 G18 H19 G20 G57 M58 K59 H60 Y61 H62 L63 K64 Q67 N74 K77 V82 S83 Q85 D102 R105 K110 L112 G113 K114 S130 R131 R132	P1 S2 R3 R5 K6 T7 R8 K9 R11 H13 V14 S15 H16 G17 H18 G19 G21 M22 K23 H24 Y25 H26 L27 K28 Q31 N38 K41 V46 S47 Q49 D66 R69 K74 L76 G77 K78 S94 R95 R96

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015934	large ribosomal subunit
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8ipx, PDBe:8ipx, PDBj:8ipx
PDBsum	8ipx
PubMed	37491604
UniProt	P46776\|RL27A_HUMAN Large ribosomal subunit protein uL15 (Gene Name=RPL27A)