Structure of PDB 8ftd Chain L

Receptor sequence
>8ftdL (length=470) Species: 562 (Escherichia coli) [Search protein sequence]
EIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPE
AITYLLEQYDRVEAEEARLSDLITGFVPELAREKFAELRAQYVVTRDTIA
TAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCVE
QCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQK
LQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKK
YTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSI
ADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPEDK
IRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLRAA
THDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIEAK
ALRKLRHPSRSEVLRSFLDD
3D structure
PDB8ftd General transcription factor from Escherichia coli with a distinct mechanism of action.
ChainL
Resolution2.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna L V98 R385 L386 K392 K418 R423 Y425 K426 T429 Y430 W433 W434 Q437 R451 H455 T583 E585 R586 Q589 V9 R242 L243 K249 K275 R280 Y282 K283 T286 Y287 W290 W291 Q294 R308 H312 T440 E442 R443 Q446
BS02 dna L T440 R562 E585 R588 T297 R419 E442 R445
BS03 1N7 L I511 G512 I368 G369
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ftd, PDBe:8ftd, PDBj:8ftd
PDBsum8ftd
PubMed38177674
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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