Structure of PDB 8cgj Chain L

Receptor sequence

>8cgjL (length=114) Species: 679895 (Escherichia coli BW25113) [Search protein sequence]

ATVNQLVRKPRNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLT
NGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCSGVK
DRKQARSKYGVKRP

3D structure

PDB

8cgj Structural conservation of antibiotic interaction with ribosomes.

Chain

Resolution

1.79 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L	A2 N5 Q6 L7 R9 R12 V21 A26 C27 P28 Q29 K30 R31 K43 K44 N46 S47 A48 R50 K51 T58 Y66 G68 G69 E70 L81 R83 G84 R86 K88 X89 P91 R94 R110 K111 Q112 A113 R114 S115 K116 V119 K120 R121	A1 N4 Q5 L6 R8 R11 V13 A18 C19 P20 Q21 K22 R23 K35 K36 N38 S39 A40 R42 K43 T50 Y58 G60 G61 E62 L73 R75 G76 R78 K80 X81 P83 R86 R102 K103 Q104 A105 R106 S107 K108 V111 K112 R113
BS02	5I0	L	K43 K88	K35 K80

Gene Ontology

	Molecular Function
GO:0000049	tRNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019843	rRNA binding
GO:0034336	misfolded RNA binding

	Biological Process
GO:0000372	Group I intron splicing
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0033120	positive regulation of RNA splicing
GO:0034337	RNA folding
GO:0046677	response to antibiotic
GO:1990145	maintenance of translational fidelity

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0022627	cytosolic small ribosomal subunit
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8cgj, PDBe:8cgj, PDBj:8cgj
PDBsum	8cgj
PubMed	37550453
UniProt	P0A7S3\|RS12_ECOLI Small ribosomal subunit protein uS12 (Gene Name=rpsL)