Structure of PDB 8c8z Chain L

Receptor sequence

>8c8zL (length=118) Species: 562 (Escherichia coli)

RLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGKFGFTSRKAAITAE
IRLSDLAKVEGGVVDLNTLKAANIIGIQIEFAKVILAGEVTTPVTVRGLR
VTKGARAAIEAAGGKIEE

3D structure

• PDB: 8c8z Cryo-EM captures early ribosome assembly in action.
• Chain: L
• Resolution: 3.12 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L	L3 N4 A9 G11 S12 K13 K14 K17 R18 L19 G20 R21 G22 I23 G24 S25 K29 T30 G32 R33 G34 H35 K63 F64 F66 R69 K70 E76 R78 N99 K109 I111 L112 R126 T128 K129	L2 N3 A8 G10 S11 K12 K13 K16 R17 L18 G19 R20 G21 I22 G23 S24 K28 T29 G31 R32 G33 H34 K37 F38 F40 R43 K44 E50 R52 N73 K83 I85 L86 R100 T102 K103

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8c8z, PDBe:8c8z, PDBj:8c8z
• PDBsum: 8c8z
• PubMed: 36797249
• UniProt: P02413|RL15_ECOLI Large ribosomal subunit protein uL15 (Gene Name=rplO)