Structure of PDB 7yxu Chain L

Receptor sequence

>7yxuL (length=213) Species: 9606 (Homo sapiens) [Search protein sequence]

DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYA
ASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYDNLPTFGQ
GTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKV
DNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG
LSSPVTKSFNRGE

3D structure

PDB

7yxu The Bispecific Tumor Antigen-Conditional 4-1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies.

Chain

Resolution

2.31 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TMO	L	P40 G41	P40 G41
BS02	MN	L	N137 N138	N137 N138

External links

PDB	RCSB:7yxu, PDBe:7yxu, PDBj:7yxu
PDBsum	7yxu
PubMed	36343381

[Back to BioLiP]