Structure of PDB 7yev Chain L

Receptor sequence
>7yevL (length=1024) Species: 538123 (Mammalian orthoreovirus 3) [Search protein sequence]
ANVWGVRLADSLSSPTIETRTRHYTLHDFYSDLDASVGKEPWRPLRNQRT
NEIVAVQLFRPLQGLVFDTQLYGFPGTFSQWEQFMKEKLRVLKYEVLRIY
PISTYNHDRVNVFVANALVGAFLSNQAFYDLLPLLIVNDTMISDLLGTGA
ALSQFFQSHGEVLEVAAGRKYLQMNNYSNDDDDPPLFAKDLSDYAKAFYS
DTYEVLDRFFWTHDSSAGVLVHYDKPTNGNHYILGTLTQMVSAPPHIINA
TDALLLESCLEQFAANVRARSAQPVTRLDQCYHLRWGAQYVGEDSLTYRL
GVLSLLATNGYQLARPIPKQLTNRWLSSFVSQVVSDGINETPLWPQERYV
QIAYDSPSVVDGATQYGYVRRNQLRLGMRISALQSLSDTPAPVQWLPQYT
IDQVAVDEGDAMVSQLTQLPLRPDYGSIWIGEALSYYVDYNRSHRVVLSS
ELPQLPDTYFDGDEQYGRSLFSLARKVGDRSLVKDTAVLKHAYQAIDPNT
GKEYLRAGQSVAYFGASAGHSGADQPLVIEPWMQGKISGVPPPSSVRQFG
YDVAKGAIVDLARPFPSGDYQFVYSDVDQVVDGHDDLSISSGLVESLLDS
CVHATAPGGSFVMKINFPTRTVWHYIEQKILPNVTSYMLIKPFVTNNVEV
FFVAFGVHQQSALTWTSGVYFFLVDHFYRYETLSAISRQLPSFGYVDDGS
SVTGIEIISIENPGFSNMTQAARVGISGLCANVGNARKSIAIYESHGARV
LTITSRRSPASARRKARLRYLPLIDPRSLEVQARTILPSNPVLFDNINGA
SPHVCLTMMYNFEVSSAVYDGDVVLDLGTGPEAKILELIPSTSPVTCVDI
RPTAQPNGCWNVRTTFLELDYLSDGWITGVRGDIVTCMLSLGAAAAGKSM
TFDAAFQQLVRVLTRSTANVLLIQVNCPTDVIRTIKGYLEIDQTNKRYKF
PKFGRDEPYSDMDSLERICRAAWPNCSITWVPLSYDLRWTKLALLESTTL
SSASVRIAELMYKYMPIMRIDIHG
3D structure
PDB7yev In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.
ChainL
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.7.7.50: mRNA guanylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM L G829 T830 I851 R852 D871 Y872 M889 L890 A895 G828 T829 I850 R851 D870 Y871 M888 L889 A894
BS02 SAM L G516 S518 G551 Y552 D577 V578 D579 G515 S517 G550 Y551 D576 V577 D578
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004484 mRNA guanylyltransferase activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0008168 methyltransferase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
GO:0032259 methylation
GO:0106005 RNA 5'-cap (guanine-N7)-methylation
Cellular Component
GO:0019028 viral capsid
GO:0039624 viral outer capsid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yev, PDBe:7yev, PDBj:7yev
PDBsum7yev
PubMed36469786
UniProtC9E871

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