Structure of PDB 7w59 Chain L

Receptor sequence
>7w59L (length=437) Species: 9606 (Homo sapiens) [Search protein sequence]
IMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEW
LDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFL
LDKAARKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGK
KAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIP
FEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKKDKQ
HLKRKADVDARKQAIRDAERVKEMKRMHLQKSEELIKKEMITMLHYDLLH
HKEELKKAQDVLVQEMEVVKQGMSHGESLEKRLEINRGHMTTEAKRAAKM
EKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAI
PRRLECLKEDVQRQQEREKELQHRYADLLLEKETLKS
3D structure
PDB7w59 Mechanism of exon ligation by human spliceosome.
ChainL
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna L Y26 R33 N161 K165 K166 R169 K170 K174 R206 L251 R252 Y23 R30 N146 K150 K151 R154 K155 K159 R191 L236 R237
BS02 rna L I4 N29 I1 N26
Gene Ontology
Molecular Function
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0071987 WD40-repeat domain binding
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0000398 mRNA splicing, via spliceosome
GO:0006281 DNA repair
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045944 positive regulation of transcription by RNA polymerase II
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005662 DNA replication factor A complex
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w59, PDBe:7w59, PDBj:7w59
PDBsum7w59
PubMed35705093
UniProtQ99459|CDC5L_HUMAN Cell division cycle 5-like protein (Gene Name=CDC5L)

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