Structure of PDB 7uzq Chain L

Receptor sequence
>7uzqL (length=388) Species: 9606 (Homo sapiens) [Search protein sequence]
MRFTFPLMAIVLEIAMIVLFGLFVEYFELYPLFQDVHVMIFVGFGFLMTF
LKKYGFSSVGINLLVAALGLQWGTIVQGILQSQGQKFNIGIKNMINADFS
AATVLISFGAVLGKTSPTQMLIMTILEIVFFAHNEYLVSEIFKASDIGAS
MTIHAFGAYFGLAVAGILYRSGLRKGHENEESAYYSDLFAMIGTLFLWMF
WPSFNSAIAEPGDKQCRAIVNTYFSLAACVLTAFAFSSLVEHRGKLNMVH
IQNATLAGGVAVGTCADMAIHPFGSMIIGSIAGMVSVLGYKFLTPLFTTK
LRIHDTCGVHNLHGLPGVVGGLAGIVAVAMGASNTSMAMQAAALGSSIGT
AVVGGLMTGLILKLPLWGQPSDQNCYDDSVYWKVPKTR
3D structure
PDB7uzq Architecture of the human erythrocyte ankyrin-1 complex.
ChainL
Resolution2.17 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR L I291 H292 F294 V340 A344 V347 A348 I270 H271 F273 V319 A323 V326 A327
BS02 CLR L Y180 L183 Y190 R323 I324 V373 L377 Y159 L162 Y169 R302 I303 V352 L356
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008519 ammonium channel activity
GO:0015200 methylammonium transmembrane transporter activity
GO:0022840 leak channel activity
GO:0030506 ankyrin binding
GO:0035379 carbon dioxide transmembrane transporter activity
Biological Process
GO:0006873 intracellular monoatomic ion homeostasis
GO:0015670 carbon dioxide transport
GO:0015701 bicarbonate transport
GO:0035378 carbon dioxide transmembrane transport
GO:0048821 erythrocyte development
GO:0060586 multicellular organismal-level iron ion homeostasis
GO:0072488 ammonium transmembrane transport
GO:0072489 methylammonium transmembrane transport
GO:0097272 ammonium homeostasis
GO:0098662 inorganic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0170014 ankyrin-1 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uzq, PDBe:7uzq, PDBj:7uzq
PDBsum7uzq
PubMed35835865
UniProtQ02094|RHAG_HUMAN Ammonium transporter Rh type A (Gene Name=RHAG)

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