Structure of PDB 7u8c Chain L

Receptor sequence

>7u8cL (length=213) Species: 10090 (Mus musculus) [Search protein sequence]

QAVVTQESALTTSPGETVTLTCRSSTGAVTTGNYPNWVQEKPDHLFTGLI
AGTNNRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWFSSHWVF
GGGTKLTVLGQPKSSPSVTLFPPSSEELETNKATLVCTITDFYPGVVTVD
WKVDGTPVTQGMETTQPSKQSNNKYMASSYLTLTARAWERHSSFSCQVTH
EGHTVEKSSSRAD

3D structure

PDB

7u8c Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin.

Chain

Resolution

1.74 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	L	Y34 N36 A51 G52 N54 N55 W93 W98	Y34 N36 A51 G52 N54 N55 W93 W98

External links

PDB	RCSB:7u8c, PDBe:7u8c, PDBj:7u8c
PDBsum	7u8c
PubMed	35512094

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