Structure of PDB 7sjp Chain L

Receptor sequence

>7sjpL (length=212) Species: 9606 (Homo sapiens) [Search protein sequence]

DIQMTQSPSSLSASVGDRVTITCRASSSVEFIHWYQQKPGKAPKPLISAT
SNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQWSSAPWTFGQG
TKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVD
NALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGL
SSPVTKSFNRGE

3D structure

PDB

7sjp Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration.

Chain

Resolution

2.1 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	L	W90 W95	W90 W95

External links

PDB	RCSB:7sjp, PDBe:7sjp, PDBj:7sjp
PDBsum	7sjp
PubMed	36064790

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