Structure of PDB 7qo5 Chain L

Receptor sequence
>7qo5L (length=388) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
EQEAHNKALNQFKRKLLEHRRYDDQLKQRRQNIRDLEKLYDKTENDIKAL
QSIGQLIGEVMKELSEEKYIVKASSGPRYIVGVRNSVDRSKLKKGVRVTL
DITTLTIMRILPRETDPLVYNMTSFEQGEITFDGIGGLTEQIRELREVIE
LPLKNPEIFQRVGIKPPKGVLLYGPPGTGKTLLAKAVAATIGANFIFSPA
SGIVDKYIGESARIIREMFAYAKEHEPCIIFMDEVDAIGGRRFSEGTSAD
REIQRTLMELLTQMDGFDNLGQTKIIMATNRPDTLDPALLRPGRLDRKVE
IPLPNEAGRLEIFKIHTAKVKKTGEFDFEAAVKMSDGFNGADIRNCATEA
GFFAIRDDRDHINPDDLMKAVRKVAEVKKLEGTIEYQK
3D structure
PDB7qo5 Allosteric control of Ubp6 and the proteasome via a bidirectional switch.
ChainL
Resolution6.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP L D313 R339 R342 D265 R291 R294
BS02 ATP L G225 G227 K228 T229 L230 E282 N328 H364 G388 A389 G177 G179 K180 T181 L182 E234 N280 H316 G340 A341
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0019904 protein domain specific binding
GO:0031625 ubiquitin protein ligase binding
GO:0036402 proteasome-activating activity
Biological Process
GO:0006289 nucleotide-excision repair
GO:0010604 positive regulation of macromolecule metabolic process
GO:0032968 positive regulation of transcription elongation by RNA polymerase II
GO:0036503 ERAD pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0070682 proteasome regulatory particle assembly
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0031597 cytosolic proteasome complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:7qo5, PDBe:7qo5, PDBj:7qo5
PDBsum7qo5
PubMed35149681
UniProtP53549|PRS10_YEAST 26S proteasome subunit RPT4 (Gene Name=RPT4)

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