Structure of PDB 7qgg Chain L

Receptor sequence

>7qggL (length=170) Species: 10116 (Rattus norvegicus) [Search protein sequence]

KENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTV
RSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGF
GIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRI
SKEEAMRWFQQKYDGIILPG

3D structure

PDB

7qgg Neuronal RNA granules are ribosome complexes stalled at the pre-translocation state.

Chain

Resolution

2.86 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L	M12 Q46 T47 C72 T73 R75 P137 G138 S140 I141 K144 R146 C150 I151 A153 K154 H155	M5 Q39 T40 C65 T66 R68 P130 G131 S133 I134 K137 R139 C143 I144 A146 K147 H148
BS02	rna	L	K19 C21 N23 C25 S51 A53 R54 F60 A69 N97 N98 S100 D101 G106 F107 G127 D129 Y131 K145	K12 C14 N16 C18 S44 A46 R47 F53 A62 N90 N91 S93 D94 G99 F100 G120 D122 Y124 K138

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding
GO:0031625	ubiquitin protein ligase binding
GO:0042975	peroxisome proliferator activated receptor binding
GO:1990948	ubiquitin ligase inhibitor activity

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006605	protein targeting
GO:0010628	positive regulation of gene expression
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504	protein localization to nucleus
GO:0042273	ribosomal large subunit biogenesis
GO:0050821	protein stabilization
GO:0140236	translation at presynapse
GO:0140242	translation at postsynapse
GO:1901796	regulation of signal transduction by p53 class mediator
GO:1901798	positive regulation of signal transduction by p53 class mediator
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process
GO:2000435	negative regulation of protein neddylation

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0032991	protein-containing complex
GO:0045202	synapse
GO:0098793	presynapse
GO:0098794	postsynapse
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7qgg, PDBe:7qgg, PDBj:7qgg
PDBsum	7qgg
PubMed	36038000
UniProt	P62914\|RL11_RAT Large ribosomal subunit protein uL5 (Gene Name=Rpl11)

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