Structure of PDB 7ojk Chain L

Receptor sequence
>7ojkL (length=1843) [Search protein sequence]
MEDDMACVKDLVSKYLADNERLSRQKLAFLVQTEPRMLLMEGLKLLSLCI
EIDSCNANGCEHNSEDKSVERILHDHGILTPSLCFVVPDGYKLTGNVLIL
LECFVRSSPANFEQKYIEDFKKLEQLKEDLKSVDINLIPLIDGRTSFYNE
QIPDWVNDKLRDTLFSLLRYAQESNSLFEESEYSRLCESLSMTSGRLSGV
ESLNVLLDNRSSHYEEIIASCHQGINNKLTAHEVKLQIEEEYQVFRNRLR
KGEITGQFLKVDKSRLLNDFNNLYVDEVTATKDNIEHLIYQFKRASPILR
FLYANIGEGIKECQMQYWRSFLNKVKSLRILNTRRKLLLIFDALILLASI
HDQTRHKCSKGWLGSCFISVNDRLVSLESTKRDLEKWVGRRQQSERSPPD
KNQILISMFQKTILKATAALKDVGISVEHYKINMEVICPDSYDLILNFDV
SGVVPTISYQRTEDEKFPFIMGGVELLESTDLERLSSLSLALVNSMKTSS
TVKLRQNEFGPARYQVVRCKEAYCQEFLLSGAEFQLIYQKTGECSKCYAI
NDNRVGEICSFYADPKRYFPAIFSAEVLQTTVSTMISWVKDCSELEEQLC
NINSLTKMILVLILAHPSKRSQKLLQNLRYFIMAYVSDYHHKDLIDKLRE
ELITDVEFLLYRLVRALVNLILSEDVKSMMTNRFKFILNISYMCHFITKE
TPDRLTDQIKCFEKFLEPKLEFGHVSINPADVATEEELDDMVYNAKKFLS
KEGCTSIKGPDYKKPGVSKRFLSLLTSSFNNGSLFKESEVKREIKDPLVK
SVVVNKYTDGSRVLNYDFNKLTALAVSQLTEVFSRKGKHLLNKQDYDYKV
QQAMSNLVLGPADLDEILLDGGASVYFDQLKETVERIIDQYDQPSVNDLD
EVVPNKFYIRLIKGELSNHMVEDFDYDVLPGNFYEEFCDAVYKNNKLKER
YFYCGTKAVATRTYFDQEYFQCFKSILLIMNANNFKFDMGRLSDDVRISE
RESNSEALSKALSLTNCTTAMLKNLCFYSQESPQSYSSTGPDTGRLKFSL
SYKEQVGGNRELYIGDLRTKMFTRLIEDYFEALSLQLSGSCLNNEREFEN
AILSMKLNVSLAHVSYSMDHSKWGPMMCPFLFLATLQNLIFLSKDLQADI
KGRDYLSTLLTWHMHKMVEIPFNVVSAMMKSFIKAQLGLKKKTTQSITED
FFYSNFQIGVVPSHVSSILDMGQGILHNTSDFYALISERFINYAISCICG
GTIDAYTSSDDQISLFDQVLTELMQRDPEEFKTLIEFHYYMSDQLNKFVS
PKSVIGRFVAEFKSRFYVWGDEVPLLTKFVAAALHNIKCKEPHQLAETID
TIIDQSVANGVPVHLCNLIQKRTLSLLQYARYPIDPFLLNCETDVRDWVD
GNRSYRIMRQIERLIPDACGRIRSMLRKLYNKLKTGQLHEEFTTNYLSSE
HLSSLSNLCELLGVEPPSESDLEFSWLNLAAHHPLRMVSSIASGFVGLCR
TLGSKCVRGPNKESLYIKSIQSLISDIQGIEPLIDSHGVQYWRVPLNIRD
GNEGVISYFRPLLWDYMCISLSTAIELGAWVLGEPKKVRVLEFFKHNPCD
YFPLKPAAGLNHIIHSLRRLYPSVFEKHILPFMSDLASTKMKWSPRIKFL
DLCVALDVNCREEHYIVLSSELRLSHTRTHTSDAVDNFMRQIYFESYVRS
FVATTRTLGSFTWFPHKTSVPEGEGLQRLGPFSSFVEKAIHKGIERPMFK
HDLMPVPLVVHRSGLWECDKKLASFTPVVQDQDLEMFVKEVGDSSLDLLI
GALSAMILDRLKLRMQWSEVDIVSMLKAAMPSNSVKVLNAVLE
3D structure
PDB7ojk Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity.
ChainL
Resolution3.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna L T341 R342 R343 R398 R399 K953 T333 R334 R335 R390 R391 K906
BS02 rna L Y471 S512 T513 Q518 R525 Y526 Q551 K552 S557 K558 Y574 K861 Y459 S500 T501 Q506 R513 Y514 Q539 K540 S545 K546 Y562 K836
BS03 ZN L K319 H364 C366 K311 H356 C358
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ojk, PDBe:7ojk, PDBj:7ojk
PDBsum7ojk
PubMed34857749
UniProtA0A3S8NV63

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