Structure of PDB 7oe3 Chain L

Receptor sequence
>7oe3L (length=1478) [Search protein sequence]
MEDDMACVKDLVSKYLADNERLSRQKLAFLVQTEPRMLLMEGLKLLSLCI
EIDSCNANGCEHNSEDKSVERILHDHGILTPSLCFVVPDGYKLTGNVLIL
LECFVRSSPANFEQKYIEDFKKLEQLKEDLKSVDINLIPLIDGRTSFYNE
QIPDWVNDKLRDTLFSLLRYAQESNSLFEESEYSRLCESLSMTSGRLSGV
ESLNVLLDNRSSHYEEIIASCHQGINNKLTAHEVKLQIEEEYQVFRNRLR
KGEITGQFLKVDKSRLLNDFNNLYVDEVTATKDNIEHLIYQFKRASPILR
FLYANIGEGNGEERHHTIKECQMQYWRSFLNKVKSLRILNTRRKLLLIFD
ALILLASIHDQTRHKCSKGWLGSCFISVNDRLVSLESTKRDLEKWVGRRQ
QSEPPDKNQILISMFQKTILKATAALKDVGISVEHYKINMEVICPDSYDL
ILNFDVSGVVPTISYQDEKFPFIMGGVELLESTDLERLSSLSLALVNSMK
TSSTCKEAYCQEFLLSGAEFQLIYQKTGECSKCYAINDNRVGEICSFYAD
PKRYFPAIFSAEVLQTTVSTMISWVKDCSELEEQLCNINSLTKMILVLIL
AHPSKRSQKLLQNLRYFIMAYVSDYHHKDLIDKLREELITDVEFLLYRLV
RALVNLILSEDVKSMMTNRFKFILNISYMCHFITKETPDRLTDQIKCFEK
FLEPKLEFGHVSINPADVATEEELDDMVYNAKKFLSKEGCTSIKGPDYKK
PGVSKRFLSLLTSSFNNGSLFKESEVKRNCTTAMLKNLCFYSQESPQSYS
STGPDTGRLKFSLSYKEQVGGNRELYIGDLRTKMFTRLIEDYFEALSLQL
SGSCLNNEREFENAILSMKLNVSLAHVSYSMDHSKWGPMMCPFLFLATLQ
NLIFLSKDLQADIKGRDYLSTLLTWHMHKMVEIPFNVVSAMMKSFIKAQL
GTTQSITEDFFYSNFQIGVVPSHVSSILDMGQGILHNTSDFYALISERFI
NYAISCICGGTIDAYTSSDDQISLFDQVLTELMQRDPEEFKTLIEFHYYM
SDQLNKFVSPKSVIGRFVAEFKSRFYVWGDEVPLLTKFVAAALHNIKCKE
PHQLAETIDTIIDQSVANGVPVHLCNLIQKRTLSLLQYARYPIDPFLLNC
ETDVRDWVDGNRSYRIMRQIERLIPDACGRIRSMLRKLYNKLKTGQLHEE
FTTNYLSSEHLSSLSNLCELLGVEPPSESDLEFSWLNLAAHHPLRMVEKV
PTIVKTIQNKLSSTFTRGAQKLLSEAINKSAFQSSIASGFVGLCRTLGSK
CVRGPNKESLYIKSIQSLISDIQGIEPLIDSHGVQYWRVPLNIRDGNEGV
ISYFRPLLWDYMCISLSTAIELGAWVLGEPKKVRVLEFFKHNPCDYFPLK
PAARVGLNHIIHSLRRLYPSVFEKHILPFSPRIKFLDLCVALDVNCEALS
LVSHIVKREEHYIVLSSELRLSHTRTHE
3D structure
PDB7oe3 Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity.
ChainL
Resolution3.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN L H316 H364 C366 H316 H364 C366
BS02 MG L D1190 D1332 E1382 D882 D1020 E1070
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7oe3, PDBe:7oe3, PDBj:7oe3
PDBsum7oe3
PubMed34857749
UniProtA0A3S8NV63

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