Structure of PDB 7nsp Chain L

Receptor sequence

>7nspL (length=144) Species: 562 (Escherichia coli) [Search protein sequence]

MRLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGQKSRSGGGVRRGF
EGGQMPLYRRLPKFGFTSRKAAITAEIRLSDLAKVEGGVVDLNTLKAANI
IGIQIEFAKVILAGEVTTPVTVRGLRVTKGARAAIEAAGGKIEE

3D structure

PDB

7nsp Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics.

Chain

Resolution

3.5 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L	N4 E10 G11 S12 K13 K14 G16 K17 R18 L19 G20 R21 G22 G24 K29 T30 G32 R33 G34 H35 K36 Q38 K39 S40 R41 S42 G43 R47 R48 F50 G52 G53 Q54 M55 Y58 R59 R60 P62 K63 F64 G65 F66 R69 A71 E76 R78 N99 K109 I111 L112 T128 K129	N4 E10 G11 S12 K13 K14 G16 K17 R18 L19 G20 R21 G22 G24 K29 T30 G32 R33 G34 H35 K36 Q38 K39 S40 R41 S42 G43 R47 R48 F50 G52 G53 Q54 M55 Y58 R59 R60 P62 K63 F64 G65 F66 R69 A71 E76 R78 N99 K109 I111 L112 T128 K129

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019843	rRNA binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0015934	large ribosomal subunit
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:7nsp, PDBe:7nsp, PDBj:7nsp
PDBsum	7nsp
PubMed	34294725
UniProt	P02413\|RL15_ECOLI Large ribosomal subunit protein uL15 (Gene Name=rplO)