Structure of PDB 7npa Chain L

Receptor sequence

>7npaL (length=617) Species: 523845 (Methanothermococcus thermolithotrophicus DSM 2095) [Search protein sequence]

YEWKLNDIVDNGICAKCGTCTVVCPNGILTFEDRPKLTEECLRKGNGMCF
EVCPRVSSGKYQIKIREKFKEEYYYGKGDVEGQDGGVVTTFLKYLLKNKK
IDGAIVVGDECWKPVSLIVQNEEDLMNTTKSKYTVSTLEALKTAGEMGLE
KVAVVGLPCQINGLRKLQYFQYLAKHDGELGKNGKPVKLPKIEYLIGLLC
TEKFEYDELKETLAKYNINMDDVEKFDIKKGKLLVYVNGEEHKIPLKEIE
LSAGCKMCRDFDAEMADVSVGCVGSPDGYSTVIIRTEKGEEIKNAIELKE
GVNLEAIEKLRDLKLNRFKKEVERRKAEDEKVSFYWTADYGGVGKRADGT
YFIRIRAKPAGWYSIDEAREILEIAEKYDGKIKMTNRGAFEIHGISGFDV
EAMVLELMEKGFITGSEGPLVRATLACPGEGNCGSGLINTTELCKILEDN
FKEHPAPYKFKIAISGCPNKCVRPQIHDIGIAGVKFPVVNEENCNGCGRC
AEVCKIEAIDIRGETSYTNYNVCIGCGKCIKACPNEGRDVKEEGFMVYVG
GKTGREVIEGVSMKLMSVEEILNLIDKVLIVYHKYAKKPQRERLAAVMAR
IGKGKFLEEVKELMEQN

3D structure

PDB

7npa Structures of the sulfite detoxifying F 420 -dependent enzyme from Methanococcales.

Chain

Resolution

1.55 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.8.98.3: sulfite reductase (coenzyme F420).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SRM	L	C428 P429 C434 S436 N470 C472 R474 K506	C427 P428 C433 S435 N469 C471 R473 K505
BS02	SF4	L	A16 R56 P159 C160 C201 T202 K204 C256 C259 K315	A15 R55 P158 C159 C200 T201 K203 C255 C258 K314
BS03	SF4	L	C25 L30 C42 R44 G46 G48 C50 E180	C24 L29 C41 R43 G45 G47 C49 E179
BS04	SF4	L	P488 C505 I507 I510 C524 I525 G526 C527 G528 C530	P487 C504 I506 I509 C523 I524 G525 C526 G527 C529
BS05	SF4	L	C428 C434 S436 G437 G467 C468 N470 C472	C427 C433 S435 G436 G466 C467 N469 C471
BS06	SF4	L	C495 N496 G497 C498 G499 C501 S517 C534 N536 G538 R539	C494 N495 G496 C497 G498 C500 S516 C533 N535 G537 R538
BS07	FAD	L	G83 Q84 D85 G87 V88 V89 T90 V107 V108 T129 K131 S132 K133 Y134 S137 L158 L199 L200 C201 T202 E203 G272 C273 V274 S281	G82 Q83 D84 G86 V87 V88 T89 V106 V107 T128 K130 S131 K132 Y133 S136 L157 L198 L199 C200 T201 E202 G271 C272 V273 S280
BS08	SF4	L	L6 C15 A16 K17 C18 G19 C21 P36 C54 P55	L5 C14 A15 K16 C17 G18 C20 P35 C53 P54
BS09	SRM	L	F353 R355 K384 T386 N387 R388 E392 Y459 K460 K462 K553 T554 G555 R556 R594	F352 R354 K383 T385 N386 R387 E391 Y458 K459 K461 K552 T553 G554 R555 R593

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding
GO:0052592	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor

View graph for
Molecular Function

External links

PDB	RCSB:7npa, PDBe:7npa, PDBj:7npa
PDBsum	7npa
PubMed	36658338
UniProt	A0A2Z5PF12

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