Structure of PDB 7lbm Chain L

Receptor sequence

>7lbmL (length=46) Species: 9606 (Homo sapiens) [Search protein sequence]

QPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

3D structure

PDB

7lbm Structure of the human Mediator-bound transcription preinitiation complex.

Chain

Resolution

4.8 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	L	C19 C36 C39	C7 C24 C27

Gene Ontology

	Molecular Function
GO:0001054	RNA polymerase I activity
GO:0001055	RNA polymerase II activity
GO:0001056	RNA polymerase III activity
GO:0003677	DNA binding
GO:0003899	DNA-directed 5'-3' RNA polymerase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

	Biological Process
GO:0006351	DNA-templated transcription
GO:0006356	regulation of transcription by RNA polymerase I
GO:0006360	transcription by RNA polymerase I
GO:0006366	transcription by RNA polymerase II
GO:0006383	transcription by RNA polymerase III

	Cellular Component
GO:0000428	DNA-directed RNA polymerase complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005665	RNA polymerase II, core complex
GO:0005666	RNA polymerase III complex
GO:0005730	nucleolus
GO:0005736	RNA polymerase I complex
GO:0005829	cytosol

External links

PDB	RCSB:7lbm, PDBe:7lbm, PDBj:7lbm
PDBsum	7lbm
PubMed	33707221
UniProt	P53803\|RPAB4_HUMAN DNA-directed RNA polymerases I, II, and III subunit RPABC4 (Gene Name=POLR2K)