Structure of PDB 7dco Chain L

Receptor sequence
>7dcoL (length=435) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
KGGVWTNVEDQILKAAVQKYGTHQWSKVASLLQKKTARQSELRWNEYLNP
KLNFTEFSKEEDAQLLDLARELPNQWRTIADMMARPAQVCVERYNRLLES
EDSKATRKIRERMLEESKRIAELQKRRELKQAGINVAIKKPKKKYGTDID
YNEDIVYEQAPMPGIYDTSTEDRQIKKKFEQFERKVNRKGLLTPKELLPH
DSGQEDNERSNIKSGKQLKSRIRKFLVQMFASLPSPKNDFEIVLSEDEKE
EDAEIAEYEKEFENERAMNEEDNFIEPPSQNDAPRVSLVAVPLAYSTLPI
PEFKNNPQSAIDNKYNLLVANAINKEPHMESRMQHITQGRTSMKIQFKTA
MPPTEVLLESIQSKVESIEQLQRKLQHVQPLEQQNNEMCSTLCHHSLPAL
IEGQRKYYADYYAYRQEIRSLEGRRKRLQAMLNSS
3D structure
PDB7dco Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2.
ChainL
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna L K35 S38 R169 R174 Y207 Y219 K27 S30 R107 R112 Y145 Y157
BS02 rna L S34 S38 K42 S26 S30 K34
Gene Ontology
Molecular Function
GO:0000386 second spliceosomal transesterification activity
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0000350 generation of catalytic spliceosome for second transesterification step
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0071006 U2-type catalytic step 1 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dco, PDBe:7dco, PDBj:7dco
PDBsum7dco
PubMed33243853
UniProtQ03654|CEF1_YEAST Pre-mRNA-splicing factor CEF1 (Gene Name=CEF1)

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