Structure of PDB 6zok Chain L

Receptor sequence

>6zokL (length=151) Species: 9606 (Homo sapiens)

ADIQTERAYQKQPTIFQNKKRVLLGETGKEKLPRYYKNIGLGFKTPKEAI
EGTYIDKKCPFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNR
FEKRHKNMSVHLSPCFRDVQIGDIVTVGECRPLSKTVRFNVLKVTKAAGT
K

3D structure

• PDB: 6zok SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation.
• Chain: L
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L	E7 F17 Y36 N39 I40 L42 K58 K59 N65 S67 I68 R69 R71 K79 K81 M82 Q83 T85 V87 Y92 H94 K98 Y99 K104 R105 H106 K107 N108 M109 E130 R132 P133 L134 S135 K136 T137 R139 F140	E6 F16 Y35 N38 I39 L41 K57 K58 N64 S66 I67 R68 R70 K78 K80 M81 Q82 T84 V86 Y91 H93 K97 Y98 K103 R104 H105 K106 N107 M108 E129 R131 P132 L133 S134 K135 T136 R138 F139
BS02	MG	L	K98 N100	K97 N99

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0032040 small-subunit processome
• GO:0045202 synapse
• GO:0070062 extracellular exosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zok, PDBe:6zok, PDBj:6zok
• PDBsum: 6zok
• PubMed: 32908316
• UniProt: P62280|RS11_HUMAN Small ribosomal subunit protein uS17 (Gene Name=RPS11)