Structure of PDB 6z6p Chain L

Receptor sequence
>6z6pL (length=661) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
ENSLSTTSKSKRQVIVPVCMPKIHYSPLKTGLCYDVRMRYHAKIFTSYFE
YIDPHPEDPRRIYRIYKILAENGLINDPTLSGVDDLGDLMLKIPVRAATS
EEILEVHTKEHLEFIESTEKMSREELLKETEKGDSVYFNNDSYASARLPC
GGAIEACKAVVEGRVKNSLAVVRPPGHHAEPQAAGGFCLFSNVAVAAKNI
LKNYPESVRRIMILDWDIHHGNGTQKSFYQDDQVLYVSLHRFEMGKYYPG
TIQGQYDQTGEGKGEGFNCNITWPVGGVGDAEYMWAFEQVVMPMGREFKP
DLVIISSGFDAADGDTIGQCHVTPSCYGHMTHMLKSLARGNLCVVLEGGY
NLDAIARSALSVAKVLIGEPPDELPDPLSDPKPEVIEMIDKVIRLQSKYW
NCFRRRHANSGCNFNEPINDSIISKNFPLQKAIRQQQQHYLSDEFNFVTL
PLVSMDLPDNTVLCTPNISESNTIIIVVHDTSDIWAKRNVISGTIDLSSS
VIIDNSLDFIKWGLDRKYGIIDVNIPLTLFEPDNYSGMITSQEVLIYLWD
NYIKYFPSVAKIAFIGIGDSYSGIVHLLGHRDTRAVTKTVINFLGDKQLK
PLVPLVDETLSEWYFKNSLIFSNNSHQCKKFGRVLRCDTDLNNIIEERFE
EATDFILDSFE
3D structure
PDB6z6p Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies.
ChainL
Resolution4.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN L D245 H247 D338 Y378 D217 H219 D310 Y350
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
GO:0006355 regulation of DNA-templated transcription
GO:0010621 negative regulation of transcription by transcription factor localization
GO:0040029 epigenetic regulation of gene expression
GO:0045944 positive regulation of transcription by RNA polymerase II
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0070823 HDA1 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6z6p, PDBe:6z6p, PDBj:6z6p
PDBsum6z6p
PubMed33523989
UniProtP53973|HDA1_YEAST Histone deacetylase HDA1 (Gene Name=HDA1)

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