Structure of PDB 6txe Chain L

Receptor sequence

>6txeL (length=478) Species: 9606 (Homo sapiens) [Search protein sequence]

MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGPLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHH
LGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRR
AYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKL
TDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKRED
YESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYC
KTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQW
CADRNFTKPQDGDVIAPLITPQKKEWND

3D structure

PDB

6txe Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Chain

Resolution

3.19 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DTP	L	V156 F157 R372 H376 K377	V42 F43 R250 H254 K255
BS02	DTP	L	V117 I118 N119	V3 I4 N5
BS03	GTP	L	Y155 V156 V378 R451	Y41 V42 V256 R329
BS04	DTP	L	R333 R352 K354 N358 K523	R211 R230 K232 N236 K401
BS05	FE	L	H167 H206 D207 D311	H53 H92 D93 D189
BS06	1FZ	L	L150 R164 D207 H215 H233 D311 K312 Y315 R366 Y374 Q375	L36 R50 D93 H101 H119 D189 K190 Y193 R244 Y252 Q253
BS07	GTP	L	K116 V117 I118 D137 Q142 R145	K2 V3 I4 D23 Q28 R31

External links

PDB	RCSB:6txe, PDBe:6txe, PDBj:6txe
PDBsum	6txe
PubMed	32576829
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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