Structure of PDB 6txc Chain L

Receptor sequence

>6txcL (length=475) Species: 9606 (Homo sapiens) [Search protein sequence]

KVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRF
EHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSH
MFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDI
CFIKEQIVGPLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHL
GIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRA
YQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLT
DNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDY
ESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCK
TAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWC
ADRNFTKPQDGDVIAPLITPQKKEW

3D structure

PDB

6txc Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Chain

Resolution

2.84 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DTP	L	V156 F157 R372 H376 K377	V41 F42 R249 H253 K254
BS02	DTP	L	I118 N119	I3 N4
BS03	GTP	L	Y155 V156 R451	Y40 V41 R328
BS04	DTP	L	R333 R352 K354 N358 K523	R210 R229 K231 N235 K400
BS05	FE	L	H167 H206 D207 D311	H52 H91 D92 D188
BS06	MG	L	D207 H233	D92 H118
BS07	0KX	L	Q149 R164 D207 H215 H233 D311 K312 Y315 D319 R366 Y374	Q34 R49 D92 H100 H118 D188 K189 Y192 D196 R243 Y251
BS08	GTP	L	K116 V117 I118 D137 R145	K1 V2 I3 D22 R30

External links

PDB	RCSB:6txc, PDBe:6txc, PDBj:6txc
PDBsum	6txc
PubMed	32576829
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

[Back to BioLiP]