Structure of PDB 6r92 Chain L

Receptor sequence
>6r92L (length=363) Species: 9606 (Homo sapiens) [Search protein sequence]
QILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPF
DRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSIT
GLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVS
ASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLAT
ASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKS
EIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPN
FKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASA
MGYHILIWSQEEA
3D structure
PDB6r92 DNA damage detection in nucleosomes involves DNA register shifting.
ChainL
Resolution4.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna L R332 F334 Q335 H336 Y356 R370 G393 I394 Y413 H414 R272 F274 Q275 H276 Y296 R310 G333 I334 Y353 H354
BS02 dna L A155 M177 K244 H333 Q335 H336 A95 M117 K184 H273 Q275 H276
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0044877 protein-containing complex binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006290 pyrimidine dimer repair
GO:0006974 DNA damage response
GO:0009411 response to UV
GO:0016567 protein ubiquitination
GO:0034644 cellular response to UV
GO:0051865 protein autoubiquitination
GO:0070914 UV-damage excision repair
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0030054 cell junction
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0031465 Cul4B-RING E3 ubiquitin ligase complex
GO:0032991 protein-containing complex
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
GO:0090734 site of DNA damage

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6r92, PDBe:6r92, PDBj:6r92
PDBsum6r92
PubMed31142837
UniProtQ92466|DDB2_HUMAN DNA damage-binding protein 2 (Gene Name=DDB2)

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