Structure of PDB 6r8y Chain L

Receptor sequence
>6r8yL (length=373) Species: 9606 (Homo sapiens) [Search protein sequence]
VGLAGPQILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRIL
QKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIG
AGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWF
CSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCC
DWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLL
TTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVG
RYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMG
DTLASAMGYHILIWSQEEARTRK
3D structure
PDB6r8y DNA damage detection in nucleosomes involves DNA register shifting.
ChainL
Resolution4.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna L R332 F334 Q335 Y356 G393 I394 Y413 R278 F280 Q281 Y302 G339 I340 Y359
BS02 dna L R112 W203 K244 P290 Q308 H333 Q335 H336 R58 W149 K190 P236 Q254 H279 Q281 H282
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0044877 protein-containing complex binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006290 pyrimidine dimer repair
GO:0006974 DNA damage response
GO:0009411 response to UV
GO:0016567 protein ubiquitination
GO:0034644 cellular response to UV
GO:0051865 protein autoubiquitination
GO:0070914 UV-damage excision repair
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0030054 cell junction
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0031465 Cul4B-RING E3 ubiquitin ligase complex
GO:0032991 protein-containing complex
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
GO:0090734 site of DNA damage

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6r8y, PDBe:6r8y, PDBj:6r8y
PDBsum6r8y
PubMed31142837
UniProtQ92466|DDB2_HUMAN DNA damage-binding protein 2 (Gene Name=DDB2)

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