Structure of PDB 6psw Chain L

Receptor sequence

>6pswL (length=473) Species: 562 (Escherichia coli) [Search protein sequence]

EIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPE
AITYLLEQYDRVEAEEARLSDLITGFVDDPELAREKFAELRAQYVVTRDT
IHATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKL
CVEQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRA
LQKLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISI
AKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAIT
RSIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMP
EDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESL
RAATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQI
EAKALRKLRHPSRSEVLRSFLDD

3D structure

PDB

6psw Stepwise Promoter Melting by Bacterial RNA Polymerase.

Chain

Resolution

3.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	L	M102 L110 N383 R385 E420 R423 Y425 K426 T429 Y430 W433 Q437 P453 T583 E585 R586	M13 L21 N243 R245 E280 R283 Y285 K286 T289 Y290 W293 Q297 P313 T443 E445 R446
BS02	dna	L	N396 R397 Q437 T509 G512 D513 E515 R562 T572 L573 R584 E585 R588	N256 R257 Q297 T369 G372 D373 E375 R422 T432 L433 R444 E445 R448

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity
GO:0005515	protein binding
GO:0016987	sigma factor activity

	Biological Process
GO:0006351	DNA-templated transcription
GO:0006352	DNA-templated transcription initiation
GO:0006355	regulation of DNA-templated transcription
GO:0009408	response to heat
GO:0010468	regulation of gene expression
GO:0045892	negative regulation of DNA-templated transcription
GO:2000142	regulation of DNA-templated transcription initiation

	Cellular Component
GO:0000345	cytosolic DNA-directed RNA polymerase complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:1903865	sigma factor antagonist complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6psw, PDBe:6psw, PDBj:6psw
PDBsum	6psw
PubMed	32160514
UniProt	P00579\|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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